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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS awards its innovative thinkers

2009-11-18

Here are, from the left: Prof. Van Wyk with first-prize winners Precious Setlaba and Themba Motsoeneng and Prof. Muriel Meiring, the students’ promoter.
Photo: Stephen Collett

The University of the Free State (UFS) recently announced the winners of the Innovation Fund Competition. This national competition, which is organised by the Department of Science and Technology aims to promote entrepreneurship through the commercialisation of the innovative ideas of young entrepreneurs.

Every participating educational institution first has an in-house competition in which a total prize money of R100 000 is at stake. At the UFS 14 business plans from students were received and evaluated by six external adjudicators. The three winners now have to take part in Phase II of the competition where 60 competitors from 20 universities will compete. The winners of the National Competition will receive prizes of up to R300 000. This money must be used for the development of the innovative idea with which the prize was won.

The first prize in the UFS’s Innovation Fund Competition of R50 000 was won by Themba Motsoeneng and Precious Setlaba from the Department of Haematology for the development of low-cost diagnostic assays for thrombotic diseases and bleeding disorders with the aim of supplying these test assays at a much lower cost to pathology laboratories all over the country. “This exciting idea appealed to many of the judges, especially because it can contribute to low cost health care in the country,” says Prof. Gerrit van Wyk, organiser of the Innovation Fund Competition at the UFS. The second prize of R30 000 was won by Charl Jaftha, MSc student in Physics. He has developed a low-cost hearing aid the size of a cigarette box. It contains a microphone and electronics to amplify the sound. The third prize of R20 000 was won by Adriaan Taylor and Jaco Brink, both MBA students. They designed a two-in-one lawnmower that would enable the average gardener with a bulky garden to shred the garden refuse and recycle it through composting or disposal through the normal disposal system. “One judge called this a novel use of existing technology,” says Prof. Van Wyk.

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