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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS launches focused research niche areas
2009-11-20

The University of the Free State (UFS) will launch its six research niche areas, the Strategic Academic Clusters, from 23-25 November 2009 on its Main Campus in Bloemfontein.

These Clusters represent a move from a fragmented to a more focused approach to research development at the UFS and will in future direct the University’s research endeavours.

“The UFS is increasingly operating in a competitive environment where South African universities no longer compete only with their national counterparts, but also internationally. With the Clusters the University will follow a focused approach to the strategic selection of niche knowledge platforms and research areas,” says Prof. Frans Swanepoel, Director of Research Development at the UFS.

The Clusters are: Water management in water-scarce areas; New frontiers in poverty reduction and sustainable development; Transformation in highly diverse societies; Technologies for sustainable crop industries in semi-arid regions; Materials and nanosciences; and Advanced biomolecular research.

“The Clusters embody the pursuit of quality and excellence and the name signifies the University’s concern not only with research, but also with under- and postgraduate teaching and learning. The vision is that the Cluster activities will not only drive world-class research outputs, but also contribute to internationally renowned graduate programme activities,” says Prof. Swanepoel.

Each of the Clusters is led by a dedicated director who provides academic leadership, facilitates cutting-edge research, leverages multidisciplinary synergies and coordinates the overall Cluster activities.

Next week’s launch programme will start on Monday, 23 November 2009 with a gala dinner, followed by a plenary symposium on Tuesday, 24 November 2009, during which the Clusters will be introduced.

Several national and international experts in the fields covered by the Clusters will take part in this symposium. They are, amongst others: Dr Danny Walmsley from St Mary’s University in Canada; Dr David Wolfe from Cornell University and Dr David Clark from the National Institute of Health, both in the USA; Mr Mark Ashley from the Desert Knowledge Cooperative Research Centre in Australia; Dr Ian Goldman from the Office of the Presidency in South Africa; Prof Peter Ewang from the South African National Development Agency; Mr Willem Louw from Sasol Technology; and Dr Pumla Gobodo-Madikizela from the University of Cape Town.

On Wednesday, 25 November 2009 each Cluster will present its own symposium.

Media release
Issued by: Lacea Loader
Deputy Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
20 November 2009

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