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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Renowned Sign Language expert heads UFS department

2009-11-27

Mr Philemon Akach

The Department of Afro-asiatic Studies, Sign Language and Language Practice in the Faculty of the Humanities at the University of the Free State recently appointed Mr Philemon Akach as its new chairperson.

Mr Akach, hitherto a senior lecturer in the department, succeeds Prof Annelie Lotriet who left the university earlier this year after having been elected to serve in the national parliament by the Democratic Alliance.

“To head the entire department has never crossed my mind because I think I am discipline oriented,” he said.

He said the confidence that his colleagues have in him gives him the impetus to succeed. “It gives me the opportunity to rethink my position within the department and the university at large,” he said.

However, his Sign Language students will be glad to know that he will not be lost to them as the result of this new responsibility.

“I cannot neglect Sign Language,” he stressed. “I have to teach because the academic side of Sign Language has to be maintained within the university, as well as nationally and internationally. I just have to divide my time between the administration of Sign Language and the teaching and research application in my discipline (Sign Language).”

To ease the load that comes with his new responsibility and the added pressure of being the only Sign Language lecturer, he said they have contracted former students to teach some courses in Sign Language.

“We have to keep in place the disciplines that keep this department’s name going,” he said.

A major challenge facing his department, according to Mr Akach, is getting more students enrolled in the disciplines offered by the department.

“To get students we need to convince them that we are the best, and that is not just a challenge for me but for the department and the lecturers in the department teaching those disciplines.”

He said he will strive for excellence in the department as part of the overall vision of the university.

“We need to get research output while not neglecting the teaching part. It is research that brings in new knowledge and it is through research that scholars expose themselves to the outside world, and by doing that they actually put the name of this university on the international map,” he said.

Mr Akach will serve in this position for the next three years.

Media release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@ufs.ac.za
26 November 2009

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