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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS serious about safe campuses
2011-02-09

Mr Willie Frankim, Head of Protection Services at the UFS, in the new control room on the Main Campus.
Photo: Dries Myburgh

The University of the Free State (UFS) officially launched its security control room recently. This new addition to the university's infrastructure, which was implemented in December 2010, has already made a contribution to the combating of crime at the UFS.

The decrease in crime statistics for January this year (5 cases), in comparison to the statistics of January 2010 (51 cases) is proof that the UFS’s new approach to combating crime on campus has an impact.
 
According to Prof. Niel Viljoen, Vice-Rector: Operations, the safety of students, lecturers and staff of the UFS is of the utmost importancet. For this reason, it is continuously reflected on about what can be done to improve the levels of safety for the respective campuses.
 
Apart from the upgraded security control room, from where, amongst others, residences, pedestrian routes, campus buildings, parking areas, entrances at gates and computer rooms at residences are observed, a number of measures have been set in place to improve the task of combating crime.
 
These measures include:
-       Security cameras in front of all the women’s residences. The UFS is in the process of also installing
        security cameras in front of the men’s residences.
-       Shrubs and trees that caused obstruction in front of cameras have been pruned.
-       Security officers patrol the pedestrian routes as well as the Red Square on foot from 06:00-22:00.
-       A security officer has been appointed at each residence to be on duty from 18:00 to 06:00
        at the residence.
-       Two vehicles patrol the Main Campus on a 24-hour basis.
-       The UFS is in die process to install alarms, which will be linked to the central security control room, 
        in all buildings.
-       In certain buildings panic buttons have been installed in strategic places.
-       Where possible, better entrance control to building, especially office blocks, has been implemented.
-       Better management and integration of the security workers who are contracted from outside.
        More security workers have also been appointed to do duty at each residence as well as on the
        pedestrian routes (during the hours indicated).
-       A survey has once again been done of all “dark spots” on the campus and better lighting is 
        currently being installed.
 
The reduced reaction times are a direct result of the operational process between security staff in the control room with met security staff that patrols the campus on foot and by vehicle


Media Release
09 February 2011
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: news@ufs.ac.za

 

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