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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

‘Leadership is formed through ethical behaviour’
2012-08-20

Mr Edward Kieswetter
20 August 2012

“Being ethical is not about what we can do, it is about what we ought to do.” This is according to Mr Edward Kieswetter, Group Executive of Alexander Forbes Limited. During his lecture to MBA students in the Business School, Mr Kieswetter allowed the audience to engage in a discussion about ethics and leadership in the business world. Mr Kieswetter is also Vice-Chairperson of the UFS Council.

Part of the lecture was discussing South Africa as a country that was not born in ethics. Mr Kieswetter commented that although context was is very important in making decisions, South African people tended to, for example, and “feed on corruption, instead of acting actively against it”. Questions about South Africa’s ethical foundation were raised. Mr Kieswetter explained that one of the greatest challenges with the South Africans was to help them understand that a person always had a choice. “If you have to compromise on your own values, you are not doing anybody justice.”

Ethics can promote common and social goals if they are not determined by what people feel and strive to reach beyond the barriers that religious beliefs put up. He shared of his life’s most valuable lessons learned about people in leadership positions. “A great leader has incredible self-awareness and displays a huge amount of humility.” He said that in life it was not about being perfect; it was rather about being authentic, even in challenging times where the outcome might affect the current situation negatively. “My greatest successes came from lessons I learned in making mistakes and growing from them.

“If you have nothing to die for, then what is there to live for?” Mr Kieswetter said when asked whether he would compromise his financial position if he did not agree with the ethics of the company he worked for. “By constantly complaining instead of progressing, we are giving up our power to change, and that is a scary thing for South Africa as a developing country.” 
 

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