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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS cracks down on crime on campus
2006-03-15

A comprehensive plan to step up the security on the Main Campus of the University of the Free State (UFS) in Bloemfontein, was approved by the Executive Management (EM) this week.

“The plan briefly comprises of the introduction of reasonable and affordable measures that will promote a safe campus and working environment,” said Rev Kiepie Jaftha, Chief Director: Community Service at the UFS.

“With the plan we want to try and create a user friendly, but safe campus,” said Rev Jaftha.

The plan is the result of an intensive investigation about campus security done by an EM task team.

The following measures will be implemented immediately in phases:

The five current vehicle entrances and exits will remain (i.e. the gate at Nelson Mandela Avenue, the gate at Roosmaryn, the gate at Agriculture, the Wynand Mouton Avenue gate and the Furstenburg Road gate).

The number of smaller pedestrian gates will be reduced and security at those remaining will be increased.
The fences around the campus will remain, upgraded and patrolled on a daily basis.

The security measures at high risk areas (e.g. the Kovsie Church) will be stepped up and the fences in these areas will be electrified.

Vehicle exit control will be stepped up at the gates by means of a mixture of electronic and compulsory visual security control.

Public areas, streets and footpaths will be patrolled and shrubs and trees will be cut and pruned. The streets, footpaths and buildings will also be lit. 

Speed reducing mechanisms will be implemented before and after the security control points at all the gates.
Additional staff will be appointed to facilitate the flow of traffic at the gates.

“Over and above these measures, the EM also approved in principle the installation of electronic equipment at all the entrance gates. This will include the installation of cameras,” said Rev Jaftha.

According to Rev Jaftha the installation of the electronic equipment will be complemented by the compulsory cutting and restarting of engines for all vehicles exiting the gates. The measure has been in force since 1 February 2006.

Last year special measures were put in place to safeguard residences and their inhabitants when security guards were placed at all the ladies residences. These measures will stay in force.

“Regular audits will be done to determine the effectiveness of the strategies and systems. Although crime in and around the campus grounds can never be completely eradicated, we want to strive to create an environment on campus and in the workplace where it can be limited,” he said.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
15 March 2006

 

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