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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

Rhodes professor calls for accountability in teacher education

2013-11-14

Prof Jean Baxen of Rhodes University and Prof Dennis Francis, Dean of the Faculty of Education of the UFS.
Photo: Stephen Collett
15 November 2013

Lecture (pdf)

“Our education system needs quality teacher education.”

This was the message from Prof Jean Baxen, Deputy Dean of Research at Rhodes University in Grahamstown. She delivered the Education Public Lecture on ‘The lives of children, citizenship and teacher education: challenges and opportunities’ at the University of the Free State’s Bloemfontein Campus.

Growing up in White River, the rural areas of Eastern Transvaal (as it was previously known), Prof Baxen took the audience on a journey of the imagination. She shared stories of how she and fellow learners walked miles to get to school and how her son found himself in a situation of being unsure about his own racial identity, questioning what it meant to be ‘coloured’. She also related stories of how teachers are not sufficiently prepared to mediate information on HIV/Aids.

These stories revealed how little teachers cared, and also how difficult and challenging it is for learners to cope in such teaching and learning environments – thus calling for quality teacher education.

She stressed the fact that quality teacher education is needed in South Africa to assist in curbing the challenges children and fellow citizens come across in our broader society. “It is important that, as teacher educators, we should groom teachers to find and understand their identity, sexuality, and also the world they live in. There is an urgent need for us to hold ourselves and others accountable and to not distance ourselves and make it someone else’s responsibility – it is our joint responsibility as citizens,” she said.

We need a pedagogy that would navigate and start formulating a language that we could use to face these challenges, she proposed.

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