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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Stochastic Modelling for Reliability from Russia
2013-12-20

 

 Prof Maxim (MS) Finkelstein’s
The Russian professor first visited our university in 1993 and loved the environment. For the last 15 years we were fortunate to have had a man of Prof Maxim (MS) Finkelstein’s (65) stature as part of our Department of Mathematical Statistics.

“I like the atmosphere, the environment and the people of the UFS,” says Prof Finkelstein. “The UFS is a real campus, not part of the city as a lot of other universities in South Africa.”

Prof Finkelstein completed his MSc in Mathematical Physics from the Leningrad State University in the USSR in 1971. Maths and Physics have been a passion of his since a young age. In 1979, Prof Finkelstein completed his PhD in Mathematical Theory of Reliability at Leningrad Elektropribor Institute. Before his career at our university, Prof Finkelstein was a Senior Researcher at St. Petersburg Elektropribor Institute and an Associate Professor at Leningrad Technological Institute.

His long list of publications includes over 170 papers and five books. His monograph Failure Rate Modelling for Reliability and Risk was published by Springer in 2008. More recently another monograph – which was co-authored with JH Cha – was published by Springer in April 2013 and is called Stochastic Modelling for Reliability: Shocks, Burn-in, and Heterogeneous Populations.

Prof Finkelstein’s research interests include mathematical theory of reliability, survival analysis, risk and safety modelling, stochastic processes and stochastics in demography. When asked about leisure and life outside of research, the devoted academic’s response was as follows…

“To have publications, you have to work all the time. I work half of Saturdays and most of Sundays,” Prof Finkelstein says. “I spend three months a year in Russia and Germany – mostly during the European summer – for my research.”
“But apart from that, I like reading – classical Russian authors mostly. I swim in the UFS’s swimming pool almost every day and I play tennis as well.”

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