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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS becomes Varsity Netball champions – again
2014-10-21



Photo: Catherine Kotze, SASPA
Kovsies has become the first team to successfully defend the Varstiy Netball title when they beat Tuks 49-42 in the 2014 final in Pretoria on Monday 20 October.

University of Pretoria (Tuks) might have been unbeaten for the entire 2014 tournament, but this did not hinder Kovsies in becoming the Varsity Netball champions for a second consecutive time.

From the outset, both these furiously focused teams fought hard and only after ample turnovers could Kovsies finally manage to open the score board.

The Mostert sisters, Karla and Tanya, won a couple of crucial balls, leaving the UFS dominating possession in the opening exchanges.

When Tuks eventually got to scoring, they could not stop the UFS from rushing to a 9-3 lead after the first ten minutes. The visitors had established a 13-5 advantage by the first break, keeping the Pretoria crowd quiet.

The home side came back shooting in the second quarter with great determination, fighting their way back into the game. Tuks ran hard, needing to work hard against Kovsies, who still managed to be in the lead with 22-16 at half-time.

Kovsies made good use of their power play early in the third quarter to stretch their lead further to 30-22. They made the most of their opportunities, going into the final quarter with a 39-31 upper hand.

Even though Tuks made a couple of changes during the final break, they could not avoid defeat in the end.

Kovsies’ Lauren-Lee Christians was also the player of the match, while the champion’s captain, Karla Mostert, was announced as the Player of the Tournament.

This hard-working defender made a number of crucial interventions alongside her sister Tanya in the final. Karla proved that she was the fans’ tournament favorite, claiming the most votes and winning a Samsung S4.

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