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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

University Assembly focuses on symbols, policies, practices, and curricula
2015-04-30

On Tuesday 28 April 2015, the University of the Free State (UFS) held a University Assembly in the Callie Human Centre on the Bloemfontein Campus, which served as a space for critical engagement among staff and students to focus on issues such as symbols, policies, practices, and curricula.

The Assembly, attended by executive and senior management, members of the UFS Council and the President of the UFS Convocation, was also streamed live to the Qwaqwa and South Campuses.

The aim of the Assembly was to deal with above-mentioned issues as transformative strategies for creating a university culture that supports its Human and Academic Projects, as embedded in responsible citizenship, human dignity, and democratic participation.

In light of inclusivity, all staff and students were invited to table their views and submit it for discussion at the assembly, to be forwarded later as recommendations to the various decision-making structures of the UFS.

A total of 12 submissions were made at the Assembly. These submissions focused on the following issues:

• The Transformative power of sport at the UFS
• Four submissions on Language Policy – whether to include other languages or going onward to be an all English institution.
• Curriculum: Substance of what we teach
• Experiences of our first-years
• Four submissions on: Statues and symbols
• The Student Representative Council’s (SRC’s) responsibility and structure.

The UFS Management considers the above-mentioned submissions, as well as the University Assembly of 28 April 2015, as the beginning of a comprehensive process to stimulate discourse about these issues on various platforms of the university.

The discussions are in an early stage and no decisions have been taken yet. Final recommendations on the issues will be submitted to the normal decision-making structures of the university, such as the Rectorate, Senate, and Institutional Forum, after which it will ultimately be presented to the UFS Council for approval.

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