Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New infrastructure development project planned for the Bloemfontein Campus
2015-06-03

Illustration by Incline Architects

The university community can look forward to two new infrastructure development projects on the Bloemfontein Campus. The construction of a new parking area for staff and students accommodated in the new Education Building, will begin as early as June 2015.

The project includes 113 parking places for students and 16 covered parking places for staff. According to Nico Janse van Rensburg, Senior Director at University Estates, the project will be tackled using several green approaches. “The parking area’s lighting will be solar-powered. The surface will not be the normal paving stone but will permit the water to drain into the ground and in this way be more environmentally friendly and minimise the greenhouse effect,” he says.

Several indigenous trees will beautify the area.

The new parking area will be situated opposite the UFS Sasol library’s student parking area, between the cricket field and the present parking area at the Education Building.

The second project involves a new roof structure at the Bloemfontein Campus’s main entrance security gate.

Since August last year, the university has been enforcing rigorous entrance controls. No person can access any of the five entrances of the Bloemfontein Campus without a valid entrance card. Should individuals not have a card, they must access the campus at Gate 5 in DF Malherbe Avenue where a temporary access card will be issued to them.  Scanning for visitors and service providers is also available at Gate 1 (Nelson Mandela Drive) and Gate 5 (DF Malherbe Avenue).

The  roof structure at the main entrance will serve as a security point. Primarily, it will provide shelter from the elements for those staff manning the area.

Nico says that the plan is to complete the projects before the end of the year. The projects are currently in the planning phase.

“The gate may possibly be closed for a day or two but the main work will be done during weekends. Certain lanes may also be closed from time to time to ensure the safety of both users and construction workers,” says Nico.

Staff and students will be advised well in advance if and when the gate will be closed.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept