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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Professor Antjie Krog to deliver public lecture at UFS Bloemfontein Campus
2015-06-19

Professor Antjie Krog – illustrious author, poet, and academic – will deliver a public lecture at the University of the Free State’s (UFS) Bloemfontein Campus. The topic of her discussion will be ‘They Couldn’t Achieve their Goal with Me: Narrating Rape during the South African War’.

Prof Krog’s lecture will be the third instalment of the Vice-Chancellor’s Lecture Series on Trauma, Memory and Representations of the Past. The lecture series is hosted by Prof Pumla Gobodo-Madikizela, Senior Research Professor in Trauma, Forgiveness, and Reconciliation Studies at the UFS, as part of a five-year research project funded by the Andrew W. Mellon Foundation.

Details of the event:

Date: Tuesday 23 June 2015
Time: 12:00
Venue: Albert Wessels Auditorium, UFS Bloemfontein Campus
Members of the public are welcome to attend
RSVP to Jo-Anne Naidoo: NaidooJA@ufs.ac.za

Acts of rape during South African War

To set the context of her lecture, Prof Krog explains that, about two months before the South African War officially ended on 31 May 1902, affidavits were taken from women about transgressions experienced at the hands of British soldiers. These acts included plunder, killing of stock, abduction, sexual assault, and rape. Her lecture is the first scholarly focus in terms of narrative and agency on the affidavits of 24 incidents of sexual assaults and rape since the 25-year embargo on these documents was lifted in 1982. The shelving of these affidavits is indicative of how even transcultural multiple processes failed to create an honest discourse in post-colonial South Africa about sexual violence.

Paving the way to healing historical wounds

The series focuses on the portrayal of trauma and memory in multiple ways – such as the narrative arts represented by Prof Krog. These forms of expression may ultimately pave the way to healing historical wounds.

“This topic is very timely, given a recent NRF grant we’ve been awarded for research on transgenerational trauma related to the South African war,” Prof Gobodo-Madikizela says in anticipation of the lecture.

Previous instalments of Vice-Chancellor’s Lecture Series

The first instalment of the Vice-Chancellor’s Lecture Series on Trauma, Memory and Representations of the Past was delivered by former Constitutional Court Judge, Albie Sachs, in which he discussed ‘Sites of memory, sites of conscience’. Internationally acclaimed composer and sound artist, Philip Miller, delivered the second lecture, ‘Disrupting the Silence: The Past and Transnational Memory’.


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