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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

New Genetics building on Bloemfontein Campus spirals into new frontiers
2015-09-11

On Thursday 3 September 2015, the Department of Genetics hosted the official opening of its new offices on the Bloemfontein Campus of the University of the Free State (UFS).

Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS, Prof Neil Heideman, Dean of the Faculty of Natural and Agricultural Sciences, and Prof Paul Grobler, Head of the Department of Genetics cut the ribbon, symbolising the opening of this building with its state-of-the-art facilities.

The new genetics building boasts a new administration block with a reception area, seven offices, a small committee room, and a seminar room for 50 people. Furthermore, the undergraduate laboratory block provides a laboratory for 150 students. The research block has facilities for 30 researchers.

This building also hosts a chemical waste sorting and storage facility. This is a first for the university.

Several sites were investigated for the new building, but due to its size and envisaged second phase, a “green fields” site was found on the western side of the campus. The main entrance caters for visitors from the north, students on foot, and those using the parking area in front of the library. The secondary south entrance is for those who use the dedicated parking area south of the building. The link between these two entrances is the spine of the building, a helix with services/buildings spaced on either side. The helix will be extended in the second phase to keep the circulation and linkage of buildings as simple as possible.

In his opening speech, Prof Grobler gave a breakdown of the history of the Department of Genetics. Today, this department, which opened its doors at the UFS in 1960, is proud of its 131 students and 46 honours students.

According to Major-General Edward Ngokha, Head of the Forensic Science Laboratory, students who graduate from the UFS in the field of genetics make excellent employees. The Forensic Science Laboratory has employed 25 honours students since the BSc Honours degree in Genetics was implemented in 2010.

“The UFS delivers education of high quality and high standards. Thank you for your contribution toward fighting crime by delivering well-prepared, committed employees,” said Major-General Ngokha.

The department presents programmes on population conservation genetics, plant molecular genetics, cytogenetics, forensic genetics, forensic science, human genetics, and behavioural genetics.

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