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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

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Center for Universal Access and Disability Support (CUADS) produces 22 graduates
2016-04-26

Description: Lutho Xintolo and mom Tags: Lutho Xintolo and mom

Lutho Xintolo (right) is one of the Centre for Universal Access and Disability Support 2016 graduates. She is currently pursuing her Honours in Psychology.
Photo: Supplied

Once again, the University of the Free State (UFS) hosted a successful series of graduations from 12-15 April 2016 where 3681 students were conferred qualifications at the Bloemfontein Campus. Among those graduating were 22 students who are affiliated with the university’s Center for Universal Access and Disability Support (CUADS).

Some of these students included Zingisa Ngwenya, who is currently busy with her second degree; Grant Lombaard, Zanele Morerwa, and Lutho Xintolo, all of whom are pursuing their Honours degrees. Louzanne Coetzee, a visually-impaired international champion athlete, was awarded a Communication: Corporate Marketing Honours degree this autumn. “We have five athletes and a cyclist with disabilities, amongst our students who are of world-class standard,” said Martie Miranda, Head of the Center.

The Center assists students to gain access to study courses, buildings, and lecture venues, learning material such as Braille, audio, enlarged print, and E-text, computer facilities with assistive technology and software and adapted hardware, and a specialised examination and test venue for alternative test and exam procedures,” Miranda added.

Students with disabilities who enrol with CUADS receive support according to their individual needs from registration through to graduation.  “During this process we identify challenges experienced in their administrative, academic, support, student life, and physical environments, and then address these challenges,” Miranda said.

Support provided by the Center includes amanuenses and extra time during tests and exams according to the student’s specific needs, (as determined through evaluation by the Extra Time Panel), together with Student Counselling and Development, academic tutors provided by the New Academic Tutor programme in collaboration with the UFS Centre for Teaching and Learning, and Sign Language interpreters or lip-speakers as well as real-time captioning.

Students with specific learning difficulties, mobility, visual, or hearing impairments, psychological, or other chronic conditions that might have a disabling effect on them, as well as those with temporary impairments, are fully supported by the CUADS. The Center strives to ensure that students achieve their full potential throughout their journey with our university.

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