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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

From Architecture graduate to fashion sensation
2016-11-14

Description:Paul Whitehead  Tags: Paul Whitehead  longdesc=

Paul Whitehead, owner and founder of
Major John.
Photo: Supplied

Paul Whitehead never thought the small business he started in his hostel room at the University of the Free State (UFS) in Huis Abraham Fischer on the Bloemfontein Campus would develop into something of magnitude.

Paul, who completed his Honours degree in Architecture in 2015 at the UFS, is currently taking a gap year due to the rapid growth of his business. Major John started back in December 2012, with Love Warrior becoming Paul’s first outlet. In 2014 Paul started manufacturing his first series of timber bow ties and after that, sales started booming.

Supplier to 16 outlets in South Africa

“We currently supply 16 outlets throughout South Africa with a range of products such as timber bow ties, genuine leather suspenders and concrete and timber desk lamps, as well as other leather products,” Paul says.

He says that a new range of nine timber bow ties is launched every four months. “The timber is recycled and the fabric is handpicked from around the country to ensure quality, thus the bow ties are hand-crafted and unique,” Paul says.

Trust your gut feeling and believe in yourself

His main goal with the timber bow ties is to expand while the unique quality of the product is not compromised. “We are also in a process of expanding the range of our products in the exclusive market.”

Paul attributes his success to delivering excellent service to people who appreciate his pride and joy, his Major John collection. He encourages future entrepreneurs to listen to others’ advice, but to trust their own gut feeling and always believe in themselves.

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