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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

A guide and a friend
2016-12-12

Description:Khothatso Mokone  Tags: Khothatso Mokone  longdesc=

Louzanne Coetzee and Khothatso Mokone.
Photo: Charl Devenish

Behind every successful Paralympic athlete is a guide, and behind blind athlete Louzanne Coetzee is none other than former Kovsie student Khothatso Mokone.

Mokone, who is a sports journalist and freelance photographer, says he is not entirely sure that his busy schedule is very balanced, but he tries to ensure he squeezes as much as possible into his day. One thing he always makes time for is his training. “As a young person, I try to take every opportunity that comes my way,” he says.

This young runner, who has been Coetzee’s guide for the past eight months, says that every race they have run together thus far has always been better than the last. “The partnership grows harmoniously every day. We talk about almost everything there is, not only running,” Mokone says.

Mokone guided Coetzee in the 1 500m of the Paralympics in Rio de Janeiro in September this year when she was disqualified. 

Mokone, who loves comedy and Dubai, is inspired by SAfm journalist and presenter Ashraf Garda. “He talks a lot about current issues that affect our country and I like his style of presenting. He is a good orator.”

Something people may not know about him is that he always walks around hopeful that the best is yet to come. “When I walk down the street, I walk with confidence and people think I have made it in life not knowing that I only have hope for a better tomorrow,” he says.

Although he is not yet as successful as he would like to be, Mokone encourages the youth to “open their eyes and ears to set realistic goals and work with patience to achieve each goal, whether short or long term”.

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