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Young PhD graduate receives prestigious bursary to advance cancer and antibiotic research

13 December 2024 | Story Martinette Brits | Photo Stephen Collett

Dr Francois Jacobs, a 30-year-old PhD graduate, has recently returned from an intensive training workshop in Harwell, Oxford, courtesy of the David Blow Bursary. This prestigious award recognises outstanding African researchers making significant contributions to macromolecular crystallography.

Dr Jacobs earned his Doctor of Philosophy degree in Chemistry on Monday, 9 December. While earning a PhD by the age of 30 was not part of his initial plan, he always aspired to pursue higher education. “From a young age, I had a strong desire to study at university. Once I got there, my ambition shifted towards obtaining a PhD,” he says, reflecting on the journey that led to this remarkable achievement.

Groundbreaking research on cancer and antibiotics

Dr Jacobs’ research addresses some of the most pressing health challenges of our time: cancer and antibiotic resistance. Using crystallography, he investigates the interactions between newly developed anticancer and antibacterial compounds and biological structures such as proteins at the atomic level. This work is vital in combating the growing threat of antibiotic-resistant bacterial infections and advancing cancer treatments.

"For me, it's about seeing humans thrive and reducing the suffering caused by illness," he explains. "I lost my grandmother to cancer, and I hope my work can spare someone else’s loved one from a similar loss."

Prestigious workshop with global experts

The "DLS-CCP4 Data Collection and Structure Solution Workshop," hosted by Diamond Light Source, offered Dr Jacobs an unparalleled opportunity to learn from leading experts in macromolecular crystallography. The workshop covered critical skills such as growing protein and DNA crystals, preventing degradation during data collection, and processing complex data. Participants also gained insights directly from the engineers and scientists behind the facility’s cutting-edge software and synchrotron technology.

“It was an incredible opportunity to learn from some of the brightest minds in the field,” says Dr Jacobs. “Not only did I acquire new skills, but I also forged new collaborations with potential research partners who can help take my work to the next level.”

The David Blow Bursary, which enabled Dr Jacobs to attend this workshop, is awarded to African researchers conducting impactful macromolecular crystallography studies.

"This training has been transformative," he adds. "It is a fantastic experience for any aspiring researcher, and I’m grateful to have had the chance to learn from these experts. Many researchers who attend workshops like this go on to work at the Diamond Light Source itself. I am eager to see where this training will take me."

A vision for the future

As Dr Jacobs continues his research, he remains driven by the hope that his work will lead to life-saving advancements in healthcare. “I want my research to provide hope and solutions for individuals battling cancer and bacterial infections,” he says.

His achievements exemplify the transformative power of education, research, and collaboration, and his story serves as an inspiration to aspiring researchers across Africa.

News Archive

Multidisciplinary conference on TB control

2003-09-22

Theme: Tuberculosis control: a multidisciplinary approach to research, policy and practice Venue: CR Swart Auditorium, University of the Free State Campus, Bloemfontein Date: 11 and 12 November 2003 Time: 11 November, 19:00-20:30 AND 12 November 08:30-17:00

Tuesday, 11 November - 19:00-20:30 (registration from 18:30) and Wednesday, 12 November - 08:30-17:00 (registration from 07:30)

The Honourable MEC for Health in the Free State will officially open the Conference on the evening of 11 November, while Prof Frederick Fourie (Vice-Chancellor and Rector of the University of the Free State) will attend to the welcoming. In addition, Prof Françoise Portaels (Institute of Tropical Medicine, Belgium) and Dr Refiloe Matji (National Department of Health, South Africa) will respectively present a global and a South African perspective on TB. The majority of the presentations will follow on 12 November.

Main thrust of Conference

The main thrust of the Conference is to disseminate both research results and policy/managerial matters relevant to TB and TB control, and to facilitate discourse among researchers and health policy makers/managers/practitioners in the field of TB control. Presenters of papers, as well as delegates are, therefore, drawn from both academic/research institutions, and from health service sectors involved in TB control in all provinces and in neighbouring countries.

Topics of presentations

A variety of topics will be dealt with during presentations, such as: New challenges in the global control of MDR-TB New strategies and policies on MDR-TB in South Africa A South African perspective on TB control A provincial perspective on implementing the national TB control policy

The role of the public district hospital in TB control Tuberculosis control through DOTS Case detection strategies

TB in children Hospital to clinic: is this the missing link? Patient compliance with DOT for TB Challenges for effective health communications in a multicultural context

The economics of TB Frequency of multiple infections with M. tuberculosis in pulmonary TB patients HIV/AIDS and TB, etc.

Speakers

Among the speakers will be Dr Victor Litlhakanyane (Head of Health: Free State); Prof Françoise Portaels and Dr Leen Rigouts (Institute of Tropical Medicine, Belgium); Dr Reliloe Matji (Director: NTBC Programme); Ntsiki Jolingana (Director: HIV, AIDS, TB and Communicable Diseases, Free State) and Annatjie Peters (Free State TB Coordinator); Dr Karin Weyer (Medical Research Council); Profs Herman Meulemans, Diana De Graeve, Luc Pauwels and Christiane Timmerman (University of Anwerp, Belgium); Dr Lara Fairall (UCT Lung Institute, University of Cape Town); Prof Frikkie Booysen (Department of Economics, University of the Free State); Christo Heunis, Ega Janse van Rensburg-Bonthuyzen, Zacheus Matebesi and Kobus Meyer (CHSR&D); Dr Mary Ednington (School of Public Health, Wits); Dr Carmen Báez and Sabine Verkuijl (ISDS); Anneke Van der Spoel-Van Dijk (Medical Microbiology, University of the Free State).

Costs

There will be no registration fees. However, delegates are expected to arrange their own transport and accommodation, or arrange for sponsorships themselves.

Contact details in case of inquiries and confirmation:

Postal Address: The Director, CHSR&D, PO Box 339, University of the Free State, Bloemfontein, 9300 Fax: 051 448 0370 Tel: 051 401 2181 OR 051 401 3256 E-mail: vrensh@mail.ufs.ac.za (Dingie van Rensburg) OR neljc@mail.ufs.ac.za (Ohna Nel)

PLEASE, CONFIRM YOUR ATTENDANCE AS SOON AS POSSIBLE, BUT AT THE LATEST BEFORE 25 OCTOBER 2003 ? BY TELEPHONE, FAX OR E-MAIL.

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