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13 December 2024 | Story Martinette Brits | Photo Stephen Collett
Dr Francois Jacobs
Dr Francois Jacobs received his Doctor of Philosophy degree in Chemistry on Monday, 9 December.

Dr Francois Jacobs, a 30-year-old PhD graduate, has recently returned from an intensive training workshop in Harwell, Oxford, courtesy of the David Blow Bursary. This prestigious award recognises outstanding African researchers making significant contributions to macromolecular crystallography.

Dr Jacobs earned his Doctor of Philosophy degree in Chemistry on Monday, 9 December. While earning a PhD by the age of 30 was not part of his initial plan, he always aspired to pursue higher education. “From a young age, I had a strong desire to study at university. Once I got there, my ambition shifted towards obtaining a PhD,” he says, reflecting on the journey that led to this remarkable achievement.

Groundbreaking research on cancer and antibiotics

Dr Jacobs’ research addresses some of the most pressing health challenges of our time: cancer and antibiotic resistance. Using crystallography, he investigates the interactions between newly developed anticancer and antibacterial compounds and biological structures such as proteins at the atomic level. This work is vital in combating the growing threat of antibiotic-resistant bacterial infections and advancing cancer treatments.

"For me, it's about seeing humans thrive and reducing the suffering caused by illness," he explains. "I lost my grandmother to cancer, and I hope my work can spare someone else’s loved one from a similar loss."

Prestigious workshop with global experts

The "DLS-CCP4 Data Collection and Structure Solution Workshop," hosted by Diamond Light Source, offered Dr Jacobs an unparalleled opportunity to learn from leading experts in macromolecular crystallography. The workshop covered critical skills such as growing protein and DNA crystals, preventing degradation during data collection, and processing complex data. Participants also gained insights directly from the engineers and scientists behind the facility’s cutting-edge software and synchrotron technology.

“It was an incredible opportunity to learn from some of the brightest minds in the field,” says Dr Jacobs. “Not only did I acquire new skills, but I also forged new collaborations with potential research partners who can help take my work to the next level.”

The David Blow Bursary, which enabled Dr Jacobs to attend this workshop, is awarded to  African researchers conducting impactful macromolecular crystallography studies.

"This training has been transformative," he adds. "It is a fantastic experience for any aspiring researcher, and I’m grateful to have had the chance to learn from these experts. Many researchers who attend workshops like this go on to work at the Diamond Light Source itself. I am eager to see where this training will take me."

A vision for the future

As Dr Jacobs continues his research, he remains driven by the hope that his work will lead to life-saving advancements in healthcare. “I want my research to provide hope and solutions for individuals battling cancer and bacterial infections,” he says.

His achievements exemplify the transformative power of education, research, and collaboration, and his story serves as an inspiration to aspiring researchers across Africa. 

News Archive

UFS research sheds light on service delivery protests in South Africa
2015-01-23

UFS research sheds light on service delivery protests in South Africa

Service delivery protests in the country have peaked during 2014, with 176 major service delivery protests staged against local government across South Africa.

A study by the University of the Free State (UFS) found that many of these protests are led by individuals who previously held key positions within the ANC and prominent community leaders. Many of these protests involved violence, and the destruction had a devastating impact on the communities involved.

This study was done by Dr Sethulego Matebesi, researcher and senior lecturer at the UFS. He focused his research on the dynamics of service delivery protests in South Africa.

Service delivery protests refer to the collective taken by a group of community members which are directed against a local municipality over poor or inadequate provision of basic services, and a wider spectrum of concerns including, for example, housing, infrastructural developments, and corruption.

These protests increased substantially from about 10 in 2004 to 111 in 2010, reaching unprecedented levels with 176 during 2014.

The causes of these protests are divided into three broad categories: systemic (maladministration, fraud, nepotism and corruption); structural (healthcare, poverty, unemployment and land issues); and governance (limited opportunities for civic participation, lack of accountability, weak leadership and the erosion of public confidence in leadership).

In his research, Dr Matebesi observed and studied protests in the Free State, Northern Cape and the North-West since 2008. He found that these protests can be divided into two groups, each with its own characteristics.

“On the one side you have highly fragmented residents’ groups that often use intimidation and violence in predominantly black communities. On the other side, there are highly structured ratepayers’ associations that primarily uses the withholding of municipal rates and taxes in predominantly white communities.”

 

Who are the typical protesters?

Dr Matebesi’s study results show that in most instances, protests in black areas are led by individuals who previously held key positions within the ANC - prominent community leaders. Generally, though, protests are supported by predominantly unemployed, young residents.

“However, judging by election results immediately after protests, the study revealed that the ANC is not losing votes over such actions.”

The study found that in the case of the structured ratepayers’ associations, the groups are led by different segments of the community, including professionals such as attorneys, accountants and even former municipal managers.

Dr Matebesi says that although many protests in black communities often turned out violent, protest leaders stated that they never planned to embark on violent protests.

“They claimed that is was often attitude (towards the protesters), reaction of the police and the lack of government’s interest in their grievances that sparked violence.”

Totally different to this is the form of peaceful protests that involves sanctioning. This requires restraint and coordination, which only a highly structured group can provide.

“The study demonstrates that the effects of service delivery protests have been tangible and visible in South Africa, with almost daily reports of violent confrontations with police, extensive damage to property, looting of businesses, and at times, the injuring or even killing of civilians. With the increase of violence, the space for building trust between the state and civil society is decreasing.”

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