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13 December 2024 | Story Martinette Brits | Photo Stephen Collett
Dr Francois Jacobs
Dr Francois Jacobs received his Doctor of Philosophy degree in Chemistry on Monday, 9 December.

Dr Francois Jacobs, a 30-year-old PhD graduate, has recently returned from an intensive training workshop in Harwell, Oxford, courtesy of the David Blow Bursary. This prestigious award recognises outstanding African researchers making significant contributions to macromolecular crystallography.

Dr Jacobs earned his Doctor of Philosophy degree in Chemistry on Monday, 9 December. While earning a PhD by the age of 30 was not part of his initial plan, he always aspired to pursue higher education. “From a young age, I had a strong desire to study at university. Once I got there, my ambition shifted towards obtaining a PhD,” he says, reflecting on the journey that led to this remarkable achievement.

Groundbreaking research on cancer and antibiotics

Dr Jacobs’ research addresses some of the most pressing health challenges of our time: cancer and antibiotic resistance. Using crystallography, he investigates the interactions between newly developed anticancer and antibacterial compounds and biological structures such as proteins at the atomic level. This work is vital in combating the growing threat of antibiotic-resistant bacterial infections and advancing cancer treatments.

"For me, it's about seeing humans thrive and reducing the suffering caused by illness," he explains. "I lost my grandmother to cancer, and I hope my work can spare someone else’s loved one from a similar loss."

Prestigious workshop with global experts

The "DLS-CCP4 Data Collection and Structure Solution Workshop," hosted by Diamond Light Source, offered Dr Jacobs an unparalleled opportunity to learn from leading experts in macromolecular crystallography. The workshop covered critical skills such as growing protein and DNA crystals, preventing degradation during data collection, and processing complex data. Participants also gained insights directly from the engineers and scientists behind the facility’s cutting-edge software and synchrotron technology.

“It was an incredible opportunity to learn from some of the brightest minds in the field,” says Dr Jacobs. “Not only did I acquire new skills, but I also forged new collaborations with potential research partners who can help take my work to the next level.”

The David Blow Bursary, which enabled Dr Jacobs to attend this workshop, is awarded to  African researchers conducting impactful macromolecular crystallography studies.

"This training has been transformative," he adds. "It is a fantastic experience for any aspiring researcher, and I’m grateful to have had the chance to learn from these experts. Many researchers who attend workshops like this go on to work at the Diamond Light Source itself. I am eager to see where this training will take me."

A vision for the future

As Dr Jacobs continues his research, he remains driven by the hope that his work will lead to life-saving advancements in healthcare. “I want my research to provide hope and solutions for individuals battling cancer and bacterial infections,” he says.

His achievements exemplify the transformative power of education, research, and collaboration, and his story serves as an inspiration to aspiring researchers across Africa. 

News Archive

An article, co-authored by Kovsies’ own Miss World, Rolene Strauss, was published recently in a medical journal
2015-02-23

Rolene Strauss

The article, which deals with research on the incidence of multiple losses by children, was published in South African Family Practice.

The study was part of the third-year research project for medical students in our Faculty of Health Sciences. Rolene worked with fellow students, Leischen Branders, Mirandie Claassen, Darienne Saaiman, and Andrea van Staden. Prof Gina Joubert from the UFS’s Department of Biostatistics and Prof Hanneke Brits were the module and study leaders.

In this study, a number of cases involving Bloemfontein children experiencing loss, as well as their reaction to it, were examined.

They divided the incidents into categories in order to address the broad definition of ‘losses’.

Approximately 69% of the children in the study have experienced three or more instances of loss in their lives. About 29% of the children have experienced loss in the category Personal Loss (assault, chronic and terminal illness, amputation, malnutrition, disability, abortion, and miscarriage). The greatest number of losses occurred in the category Interpersonal Loss (87%). This group of children has had to deal with the death of one or more parents/caregivers, drug and alcohol abuse, domestic violence, divorce, homelessness, and instability. In the category, Environmental Loss, xenophobia, unsafe living conditions, inadequate support, poverty, and unemployment were looked at. A total of 82% of the children in the group have experienced losses.

Prof Hanneke Brits, study leader of the group, says the extent of multiple losses by children is a topic that hasn’t been investigated widely.

“The study shows that children should receive special attention in order to help them process the trauma. Supportive care and inter-professional services play a major role in this regard.”

 

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