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13 December 2024 | Story Martinette Brits | Photo Stephen Collett
Dr Francois Jacobs
Dr Francois Jacobs received his Doctor of Philosophy degree in Chemistry on Monday, 9 December.

Dr Francois Jacobs, a 30-year-old PhD graduate, has recently returned from an intensive training workshop in Harwell, Oxford, courtesy of the David Blow Bursary. This prestigious award recognises outstanding African researchers making significant contributions to macromolecular crystallography.

Dr Jacobs earned his Doctor of Philosophy degree in Chemistry on Monday, 9 December. While earning a PhD by the age of 30 was not part of his initial plan, he always aspired to pursue higher education. “From a young age, I had a strong desire to study at university. Once I got there, my ambition shifted towards obtaining a PhD,” he says, reflecting on the journey that led to this remarkable achievement.

Groundbreaking research on cancer and antibiotics

Dr Jacobs’ research addresses some of the most pressing health challenges of our time: cancer and antibiotic resistance. Using crystallography, he investigates the interactions between newly developed anticancer and antibacterial compounds and biological structures such as proteins at the atomic level. This work is vital in combating the growing threat of antibiotic-resistant bacterial infections and advancing cancer treatments.

"For me, it's about seeing humans thrive and reducing the suffering caused by illness," he explains. "I lost my grandmother to cancer, and I hope my work can spare someone else’s loved one from a similar loss."

Prestigious workshop with global experts

The "DLS-CCP4 Data Collection and Structure Solution Workshop," hosted by Diamond Light Source, offered Dr Jacobs an unparalleled opportunity to learn from leading experts in macromolecular crystallography. The workshop covered critical skills such as growing protein and DNA crystals, preventing degradation during data collection, and processing complex data. Participants also gained insights directly from the engineers and scientists behind the facility’s cutting-edge software and synchrotron technology.

“It was an incredible opportunity to learn from some of the brightest minds in the field,” says Dr Jacobs. “Not only did I acquire new skills, but I also forged new collaborations with potential research partners who can help take my work to the next level.”

The David Blow Bursary, which enabled Dr Jacobs to attend this workshop, is awarded to  African researchers conducting impactful macromolecular crystallography studies.

"This training has been transformative," he adds. "It is a fantastic experience for any aspiring researcher, and I’m grateful to have had the chance to learn from these experts. Many researchers who attend workshops like this go on to work at the Diamond Light Source itself. I am eager to see where this training will take me."

A vision for the future

As Dr Jacobs continues his research, he remains driven by the hope that his work will lead to life-saving advancements in healthcare. “I want my research to provide hope and solutions for individuals battling cancer and bacterial infections,” he says.

His achievements exemplify the transformative power of education, research, and collaboration, and his story serves as an inspiration to aspiring researchers across Africa. 

News Archive

The science of translation
2015-09-16

What is the relationship between a translator, information, and an audience? Professor Christiane Nord explored the connection in a series of lectures hosted by the Linguistics and Language Practice Department and the Department of Hebrew of the University of the Free State (UFS) Bloemfontein Campus.

Since 2007, the professor for Translation Studies has been a research associate and professor extraordinary in the department, assisting translation and interpreting students in gaining a global perspective on their disciplines.

The world-renowned German scholar and trained translator for Spanish and English is also an author, with over 200 published articles on the so-called Skopos Theory, which formed the basis of the lectures on 7 and 8 September 2015. The addresses were centered on the functionality and limitations of translations.

Translation as a purposeful activity

According to Prof Nord, all translations should be geared towards conveying messages which the audience understands. This communicative purpose involves taking into consideration the cultural background of the recipient.

As a seasoned practitioner, Prof Nord has been guided by Skopos Theory in her teaching endeavours. Hence her firm stance: “If you do not have a theory, you cannot justify your translational decisions.”

Within the context of the Skopos Theory, she explains that, in order to produce a functional translation, the translator must analyse the purpose of the translated text, which includes the questions for whom, when, where, and through which medium will it reach the intended audience.

How to deal with doubt in functional translation

“Doubt is something we are accompanied by when we’re translating.” Such doubt may be caused by “insufficient proficiency with regards to source and target languages and cultures, domain and terminological knowledge, and knowledge in translation theory and methodology,” said Prof Nord. However, the top-down approach offers a solution to overcome uncertainty, at least to some extent. This approach considers, first and foremost, the target audience for which the translation is tailored. Based on this consideration, the translator is able to determine the approach that is most suitable for the audience, hence eliminating doubt.

In sum, the extraordinary professor asserted that there are no rules for translation, contrary to popular belief. According to Prof Nord, the main focus of a translator or interpreter should be to produce texts in the target language and culture which meet the requirements of the translation brief set by the client or commissioner.

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