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13 December 2024 | Story Martinette Brits | Photo Stephen Collett
Dr Francois Jacobs
Dr Francois Jacobs received his Doctor of Philosophy degree in Chemistry on Monday, 9 December.

Dr Francois Jacobs, a 30-year-old PhD graduate, has recently returned from an intensive training workshop in Harwell, Oxford, courtesy of the David Blow Bursary. This prestigious award recognises outstanding African researchers making significant contributions to macromolecular crystallography.

Dr Jacobs earned his Doctor of Philosophy degree in Chemistry on Monday, 9 December. While earning a PhD by the age of 30 was not part of his initial plan, he always aspired to pursue higher education. “From a young age, I had a strong desire to study at university. Once I got there, my ambition shifted towards obtaining a PhD,” he says, reflecting on the journey that led to this remarkable achievement.

Groundbreaking research on cancer and antibiotics

Dr Jacobs’ research addresses some of the most pressing health challenges of our time: cancer and antibiotic resistance. Using crystallography, he investigates the interactions between newly developed anticancer and antibacterial compounds and biological structures such as proteins at the atomic level. This work is vital in combating the growing threat of antibiotic-resistant bacterial infections and advancing cancer treatments.

"For me, it's about seeing humans thrive and reducing the suffering caused by illness," he explains. "I lost my grandmother to cancer, and I hope my work can spare someone else’s loved one from a similar loss."

Prestigious workshop with global experts

The "DLS-CCP4 Data Collection and Structure Solution Workshop," hosted by Diamond Light Source, offered Dr Jacobs an unparalleled opportunity to learn from leading experts in macromolecular crystallography. The workshop covered critical skills such as growing protein and DNA crystals, preventing degradation during data collection, and processing complex data. Participants also gained insights directly from the engineers and scientists behind the facility’s cutting-edge software and synchrotron technology.

“It was an incredible opportunity to learn from some of the brightest minds in the field,” says Dr Jacobs. “Not only did I acquire new skills, but I also forged new collaborations with potential research partners who can help take my work to the next level.”

The David Blow Bursary, which enabled Dr Jacobs to attend this workshop, is awarded to  African researchers conducting impactful macromolecular crystallography studies.

"This training has been transformative," he adds. "It is a fantastic experience for any aspiring researcher, and I’m grateful to have had the chance to learn from these experts. Many researchers who attend workshops like this go on to work at the Diamond Light Source itself. I am eager to see where this training will take me."

A vision for the future

As Dr Jacobs continues his research, he remains driven by the hope that his work will lead to life-saving advancements in healthcare. “I want my research to provide hope and solutions for individuals battling cancer and bacterial infections,” he says.

His achievements exemplify the transformative power of education, research, and collaboration, and his story serves as an inspiration to aspiring researchers across Africa. 

News Archive

Researcher in Otorhinolaryngology advocates education in deafness and hearing loss
2015-12-17

Description: Dr Magteld Smith  Tags: Dr Magteld Smith

Dr Magteld Smith

The annual International Day of Persons with Disabilities falls on 3 December. Statistics reveal that 7.5% of the South African population suffer from some form of physical disability.

More than 17 million people in South Africa are dealing with depression, substance abuse, anxiety, bipolar disorder, and schizophrenia - illnesses that round out the top five mental health diagnoses, according to the Mental Health Federation of South Africa. The South African Federation for Mental Health is the umbrella body for 17 mental health societies and numerous member organisations throughout the country.

On disability, world-renowned author Helen Keller, who was both deaf and blind, once said that the problems that come with being deaf are deeper and more complex than those of blindness, and is a much worse misfortune. For it means the loss of the most vital stimulus - the sound of the voice that brings language, sets thoughts astir, and keeps us in the intellectual company of man.

According to Dr Magteld Smith, lecturer and researcher in the Department of Otorhinolaryngology at the University of the Free State (UFS), hearing loss of any degree at any age can have far-reaching psychological and sociological implications which affect an individual’s day-to-day functioning, and might prevent him or her from reaching their full potential. She says that even though advancements have been made in aiding deaf persons, there’s still considerable room for improvement. She’s making it her mission to bring about changing the stigmatisation around deafness, and the different choices of rehabilitation.

Dr Smith was born with bilateral (both ears) severe hearing loss, and became profoundly deaf, receiving a cochlear implant in 2008. Not letting this hinder her quality of life, she matriculated in 1985 at a School for the Deaf in Worcester. Today she is the only deaf medical-social researcher in South Africa.

Her research focuses on all aspects of deafness and hearing loss. Through first-hand experience, she knows that a loss of hearing can be traumatic as it requires adjustments in many areas of life which affect a person’s entire development. However, she has not let her deafness become a stumbling block. She has become the first deaf South African to obtain two Master’s degrees and a PhD, together with various other achievements.

Her work is aimed at informing and educating people in the medical profession, parents with children, and persons with various degrees and types of hearing loss about the complexities of deafness and hearing loss. She believes that, with the technological advancements that have been made in the world, deaf people can become self-sufficient and independent world changers with much to contribute to humanity.

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