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15 January 2024 | Story André Damons | Photo Supplied
CHPC students read more
The top finishing UFS team, Team 5, consisting of Nhlonipho Shezi, Kgoboketso Mphahlele, Albert van Eck (mentor), Itumeleng Khaka, and Bophelo Pharasi came third during the national round of the National Integrated Cyber Infrastructure Systems (NICIS) CHPC’s Student Cluster Competition.

Two students from the University of the Free State (UFS) who took part in the National Integrated Cyber Infrastructure Systems (NICIS) CHPC Student Cluster Competition were selected as part of the National Team to compete at the International Supercomputing Conference (ISC) Student Cluster Competition next year.

Itumeleng Khaka and Nhlonipho Shezi, both currently studying towards a Bachelor of Science degree in Information Technology majoring in Computer Science and Business Management, were part of one of the university’s teams (Team 5) that took third place during the national round of the competition.

Bophelo Pharasi (Bachelor of Science in Information Technology majoring in Computer Science and Business Management) and Kgoboketso Mphahlele (Bachelor of Computer Information Systems) were the other team members, and Albert van Eck, Head of the eResearch and High-Performance Computing Unit, was their mentor. The UFS entered three teams for the competition. 

Another student, Limpho Senatla (Bachelor of Science in Information Technology), was awarded the prize for the female student with the most potential during this competition. Some of the prizes awarded to her include an opportunity to work under the mentorship of sponsors such as Tsolo.io, Diplomics, Intel, and the South African Radio Astronomy Observatory (SARAO).

The other two teams that also participated were Team OptiCompute (mentor: Hendrik van Heerden), consisting of Senatla, Siphesihle Mvelase (Bachelor of Science in Information Technology majoring in Computer Science and Business Management), Ziphezinhle Malinga (Bachelor of Science in Information Technology majoring in Computer Science and Business Management), Ennosse Mkhutyukelwa (Bachelor of Science in Information Technology majoring in Computer Science and Chemistry); and Team KKRT (mentor: Zirke le Roux), consisting of Kananelo Nyakallo Mofokeng (Bachelor of Science in Information Technology majoring in Computer Science and Physics), Boitumelo Ramasike (Bachelor of Science in Information Technology majoring in Computer Science and Business Management), Kamohelo Kolanchu (Bachelor of Science in Information Technology majoring in Computer Science and Mathematics), and Thabang Maokeng (Bachelor of Computer Information Systems).

Highly stressful and demanding

“Since 2017, the UFS has competed in the CHPC Student Cluster Competition, with various successful outcomes. This year was no exception, with Team 5 winning third place at the national round. All teams endured a highly stressful and demanding round where external factors such as load shedding, late and incomplete hardware deliveries, extreme heat, and sleep deprivation played a role,” says Van Eck.

According to its website, the Centre for High-Performance Computing (CHPC), a division of the Council for Scientific and Industrial Research (CSIR), annually hosts a Human Capital Development (HCD) programme for undergraduate students currently enrolled in Science, Technology, Engineering and Mathematics (STEM) fields at South African universities. They undergo training that will take them from zero knowledge of HPC to being able to build mini clusters through various rounds.

The competition is held annually and consists of three rounds: a selection, national, and international round. A team composed of four undergraduate (second-year) students can enter the competition.

This year, twenty teams from eight universities participated in the selection round. Each year, this round is hosted at a different university in the country, with the UFS Bloemfontein Campus playing host this year from 10 to 15 July. During the first round, students were exposed to various technologies and concepts used in HPC and scientific computing. Students were then evaluated according to their technical skills acquired during the selection round, and had to design, present, and defend a cluster design with its network topology.

The national round, for which all three UFS teams qualified, was held at the Kruger National Park from 3 to 8 December.

Travel internationally

According to Van Eck, the students were given a limited budget to procure a small cluster for this round. Students then had to assemble the cluster and start configuring it during this round. After installing and configuring their clusters, students had to install and optimise scientific software. Installing and optimising scientific software is quite challenging. One must consider various technologies such as hardware components, networking, operating systems, compilers, intercommunication between processes, and the functionality of the software.

The winning team in the national round is combined with two members of either the second or third-place winners and two reserves selected from those teams. This team will travel to Austin, Texas, early next year to visit the Texas Advanced Computing Centre (TACC). Students will also undergo more training at Dell Labs in the USA.

The team will compete at the International Supercomputing Conference (ISC) Student Cluster Competition (SCC) against teams from across America, Europe, and Asia. This competition is held in Germany and sees the best international students competing in the final round. The South African teams have won this round on several occasions.

“The competition takes all students out of their comfort zones. The technologies and methodologies they are exposed to are state-of-the-art in theoretical and computational sciences. In the first round, students are trained by industry professionals on concepts they would otherwise never be exposed to. They come into contact with multiple disciplines within IT, engineering, and some scientific fields. The learning curve during this competition is immense, but students who rise to the challenge reap the benefits in the long run. With prizes such as laptops, prize money, and mentorship from the industry, multiple opportunities can be utilised,” says Van Eck.

Exposure to various technologies

Van Eck says even members from teams that do not make it into the top positions can benefit from exposure to various technologies and networking with other delegates. Leveraging knowledge attained during the competition also enhances one's ability to apply knowledge to other parts of one's career.

“To become an HPC specialist, one must master various field-specific domains, and each of these domains can become a career in itself should a student identify a specific field of more interest to them. This type of exposure is usually only experienced once one enters the workforce. It may be difficult and costly to enter a specific domain by that time. Earlier exposure during a competition like this can assist a student in identifying which fields of science, engineering, or IT they would like to focus on and perhaps later specialise in.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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