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01 March 2024 | Story VALENTINO NDABA | Photo SUPPLIED
Prof Geo Quinot and with Ntando Ncamane
Prof Geo Quinot from Stellenbosch University, pictured with Ntando Ncamane, a Lecturer in the UFS Department of Mercantile Law.

The Department of Mercantile Law at the University of the Free State (UFS) recently spearheaded a Legal Education Colloquium, marking the genesis of a groundbreaking book project with the vision of revitalising legal education across South Africa. Attended by luminaries from academia, legal practitioners, and students, the event featured Professor Geo Quinot from Stellenbosch University, a distinguished figure renowned for his profound insights into legal education, as the keynote speaker.

Ntando Ncamane, a Lecturer in Mercantile Law, provided a comprehensive overview of the colloquium’s objectives, outcomes, and future trajectory. "The dynamic evolution of legal frameworks, notably the promulgation of the Constitution, statutes, and landmark cases, has necessitated a reformation in South African legal education,"  Ncamane remarked. He underscored the pivotal role of digital transformation, particularly in the context of the pandemic, and emphasised the joint commitment of regulatory bodies and academic institutions towards fostering an ethos of engaged scholarship. The colloquium served as a platform to dissect and explore transformative trends, inviting stakeholders to deliberate on novel perspectives and navigate emerging challenges in legal education.

Insights from Prof Geo Quinot and eminent experts

Reflecting on the invaluable insights garnered from deliberations, Ncamane highlighted Professor Quinot's keynote address, which advocated for a reimagining of collaborative endeavours, particularly involving students. Discussions spanned an array of topics including innovative methodologies, enhancing assessment frameworks, leveraging digital platforms for education, integrating competition law into curricula, promoting engaged scholarship, nurturing emotional intelligence among students, and addressing complexities within modules such as civil procedure. Stimulating dialogues on decoloniality, decolonisation, and ubuntu ethos also permeated the discourse. 

The forthcoming book, a culmination of the colloquium, will traverse themes encompassing Digital Education, Student Engagement, and Decolonisation. Ncamane elucidated, "Contributors will be aligned with one of the themes based on the relevance of their contributions…A call for papers was issued, eliciting abstract submissions from prospective contributors."

Scholars hailing from diverse academic institutions including the UFS, University of the Witwatersrand, University of Limpopo, University of Fort Hare, North-West University, Varsity College, and Stellenbosch University, have been enlisted for participation. Each chapter will undergo a peer review process, ensuring scholarly rigour and academic excellence. 

Role and impact of the book

Articulating the envisioned role of the book, Ncamane underscored its potential to reshape legal education and curriculum development. He said, "The book offers key approaches that can be adopted by legal scholars to improve teaching methods, ultimately benefiting students, academics, and society at large."

With regards to timelines, Ncamane indicated that the publication is slated for release in late 2024 or early 2025, contingent upon the duration of the blind review process and editorial refinement. The Legal Education Colloquium and its ensuing book project exemplify a concerted endeavour to address the evolving imperatives of legal education, foster scholarly discourse, and contribute meaningfully to the enhancement of legal praxis in South Africa.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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