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10 May 2024 | Story Leonie Bolleurs | Photo supplied
Maureen Maisiri - Keynote Speaker PhD Candidate UFS
Delivering the keynote address at the first PhD Colloquium in Disaster Risk Management and Climate Change Adaption, Maureen Maisiri said that it is important to stop taking approaches that do not include people affected by disasters and climate change.

In the midst of South Africa's complex socioeconomic challenges, including poverty, food insecurity, and environmental degradation, a study tiled: Nature-based solutions practices: implications on farm performance, sustainable environment, poverty reduction and food security among South African households? explores the potential of nature-based solutions (NBS) to address these pressing issues. Focused on disaster risk management and climate change adaptation, this study examines the adoption of NBS and its impact on environmental sustainability, agricultural productivity, and community resilience. Collins Okolie aims to offer valuable insights for policy makers, farmers, and communities by investigating the viability of NBS as a strategy for mitigating disaster risk and managing climate change. His work emphasises the importance of raising awareness about NBS and its transformative potential in enhancing farm performance, food security, and poverty reduction.

This study was one of a number of studies discussed during the first three-day PhD Colloquium in Disaster Risk Management and Climate Change Adaptation hosted by the Disaster Management Training and Education Centre for Africa (DiMTEC) at the University of the Free State (UFS).

Becoming a centre of excellence

According to Dr Olivia Kunguma, Lecturer in DiMTEC who acted as chair, the colloquium was inspired by DiMTEC’s vision to become a centre of excellence. It aimed to support PhD candidates and find solutions and recommendations for the increasing incidents and declared disasters in Africa. She added that the colloquium was also the centre’s way of contributing to the achievement of global targets, such as the Sendai Framework for Disaster Risk Reduction 2015-2030 priorities, the Paris Climate Change Agreement of 2015, and the Sustainable Development Goals.

Among the more than 80 delegates who attended the colloquium were key stakeholders in disaster management, including representatives from the National Disaster Management Centre and the Gauteng Provincial Disaster Management Centre, in addition to the PhD candidates. The event also received support from UFS research structures, including the Directorate Research Development represented by its Director, Dr Glen Taylor, and the Faculty of Natural and Agricultural Sciences, represented by the Dean, Prof Paul Oberholster. External stakeholders in attendance included Counsellor Lulama Titi-Odili, the Deputy Mayor of the Mangaung Metropolitan Municipality, and Khotso Tsotsotso, the acting Head of the Old Mutual Foundation. The event was also sponsored by the Old Mutual Foundation, the Gauteng Provincial Disaster Management Centre, and the National Disaster Management Centre. “Having the Old Mutual Foundation as the primary sponsor is exciting for the disaster management fraternity, as it will see insurance companies take a growing interest in disaster risk management, resilience building, and climate change adaptation,” said Dr Kunguma.

Dr Kunguma pointed out the excitement and productive engagement between the audience and the PhD candidates as a particular highlight of the event. She emphasised the rigorous and scientific feedback received by the candidates, allowing them to reflect on their research motivation, perspectives, and future implications. The event provided an invaluable opportunity for PhD candidates to receive practical, social, and scientific feedback from both research experts and industry professionals. Dr Kunguma remarked, “The feedback and engagements have improved their work, and sharpened their presentation skills and confidence in their work and in themselves.”

Additionally, the initiative provoked praise from the Deputy Mayor, who underlined her role in advocating for increased funding for disaster management. Counsellor Titi-Odili stressed the importance of budgeting sufficiently for disasters. She acknowledged that disasters often originate at the local level and advocated for adjustments in the disaster declaration process. She also proposed the involvement of interns or graduates in government disaster management efforts.

Jurgens Dyssel from the National Disaster Management Centre also provided his input on the value of this initiative. He indicated that such a platform brings new knowledge that should be aligned with industry needs for translation into community impact. He suggested that the colloquium be aligned with the National Disaster Management Research Agenda, a repository for all research in disaster and climate studies.

Tshepo Motlhale, Chief Director of the Gauteng Provincial Disaster Management Centre, added that the colloquium is an innovative platform for diversifying all aspects of interventions and creating a space to enhance partnerships and collaborations to come up with solutions.

Blended systematic and sustainable solutions

Giving a voice to the PhD candidates was Maureen Maisiri, who was also appointed as the keynote speaker for this event. According to her, there is a need to create blended systematic and sustainable solutions and to stop taking approaches that do not include people affected by disasters and climate change. Maisiri encouraged fellow PhD candidates to work in teams, to appreciate diversity, and to be disciplined.

In the panel discussion on My PhD journey and contribution to Disaster Risk Management and Climate Change Adaptation, the work of Daizy Nalwamba and Zukiswa Poto investigated critical aspects of disaster risk management and climate change adaptation. Nalwamba's study in Zambia explored the effectiveness of environmental education in promoting sustainable practices, revealing gaps between knowledge and practical application. Meanwhile, Poto's research in South Africa highlighted the need to prioritise economic resilience in disaster management legislation, advocating for proactive measures to support business continuity and community resilience.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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