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09 May 2024 | Story André Damons | Photo Supplied
Science Oscars Winners 2024
From top-left to right: Drs Claudia Ntsapi, Mpho Mafa, Angélique Lewies, Yolandi Schoeman, and Bimo Nkhata are dedicated to innovative solutions spanning from addressing brain aging to enhancing food security, developing xenograft scaffolds for regenerative medicine, transforming degraded terrains into vibrant landscapes, and protecting precious water resources. Prof Sandy-Lynn Steenhuisen's research team investigates the dynamics of mountain ecosystems in terms of pollination, seed dispersal and other aspects of plant reproductive ecology and vegetation community, largely assessing the impacts of climate change and invasive alien plants on these systems.

A neuropsychologist, a biochemist, a cell biologist, and an ecological engineer from the University of the Free State (UFS) have all received their first nomination in this year’s NSTF-South32 Awards. The four researchers have been nominated in the TW Kambule-NSTF Award: Emerging Researcher category.

These emerging researchers are part of a group of nine UFS researchers nominated for the ‘Science Oscars of South Africa’. Two other researchers; Prof Sandy-Lynn Steenhuisen, Associate Professor and Subject Head: Department of Plant Sciences and the Afromontane Research Unit (ARU), and Dr Bimo Abraham Nkhata, Senior Lecturer at the UFS Centre for Environmental Management (CEM), have also been nominated in the categories Green Economy and NSTF-Water Research Commission (WRC) respectively.

Preserving human brain health with age

Dr Claudia Ntsapi, who is passionate about exploring innovative solutions to address the gradual decline in normal brain function associated with aging, says the research that led to her nomination focuses on preserving human brain health to delay or prevent age-related conditions, such as Alzheimer's disease.

The nomination, she says, reaffirms the growing impact of their research efforts and reinforces her commitment to contributing toward enhancing the quality of life for individuals affected by age-related neurodegenerative diseases and their families.

“Leveraging advanced cell-based models that mimic human cellular environments, my research investigates the potential benefits of medicinal plants as supplementary treatments for neurodegenerative diseases. By utilising cutting-edge techniques, such as the innovative CelVivo ClinoStar 2 System, we strive to gain insights into the safety and efficacy of underexplored medicinal plants in preserving cognitive function and slowing disease progression.

“By exploring the untapped potential of bioactive compounds found in medicinal plants and nutraceuticals, our research group aims to contribute to the identification of novel therapeutic targets and the discovery of new avenues for intervention to improve the quality of life for individuals affected by age-related brain conditions,” Dr Ntsapi explains.

Improving food security, and renewable resources for circular economy 

A humbled and excited Dr Mpho Mafa says his nomination is based on the impact and quality of research his group (carbohydrates and enzymology Laboratory: CHEM-Lab) produced since 2020.

“My research group uses biochemical, enzymological, and biotechnological techniques to study the physiological and biochemical functions of carbohydrate-active enzymes (CAZymes) and carbohydrate metabolism during wheat interaction with rust disease-causing fungi or wheat infestation by a virulent Russian wheat aphid (RWA) biotype,” he said.

“The findings from these studies allow us to identify the key genes, enzymes, metabolites and biochemical processes used by wheat plants to reduce the effects of rust fungi or RWA damage, leading to improved plant health and yield. Thus, my research group uses innovative biochemistry/biotechnology approaches to protect the second-most important grain crop in South Africa against rust diseases and aphid attack.”

In addition, Dr Mafa uses the CAZymes in the field of lignocellulosic biorefinery to produce value-added products (VAPs), such as fermentable carbohydrates used in the production of second-generation biofuel for the circular economy. 

“I want to thank the NRF-Thuthuka for funding the lignocellulosic biorefinery project which aims to improve the conversion rate of lignocellulose to VAPs through enzymatic catalysis processes.” Dr Mafa says.

Tissue engineering and regenerative medicine

According to Dr Angélique Lewies, this achievement was truly a team effort from her dedicated colleagues at the Robert WM Frater Cardiovascular Research Centre. She says the nomination validates her team’s hard work and dedication, and recognises their efforts to advance the fields of tissue engineering and regenerative medicine.

“Our team has developed xenograft tissue scaffolds from non-human sources with a reduced potential to induce immune responses in human recipients, which are common causes of calcification, degradation, and failure of surgical scaffolds. We pioneered a processing technique that promotes cell infiltration, remodelling, and regeneration of the tissue. These xenografts are versatile, showing promise for use in various surgical disciplines, including cardiac and plastic surgery,” Dr Lewies says.

Induced pluripotent stem cells created from recipient skin cells, she explains, can be combined with the processed tissue, creating custom tissue products for improved patient-specific outcomes. Their research has successfully developed a method for processing bovine pericardium that not only mitigates calcification but also preserves mechanical properties and enhances host cell infiltration, significantly increasing the longevity of the tissue when used clinically.

Environmental and sustainability challenges

“This nomination is both an honour and an affirmation of the importance of ecological engineering in addressing today’s environmental challenges,” says Dr Yolandi Schoeman.

“It represents a recognition of the value and impact of integrating natural processes with engineering principles to create sustainable and resilient ecosystems whilst addressing some of our most pressing sustainability challenges,” Dr Schoeman says.

Her work primarily revolves around ecological engineering — a field that combines natural processes with engineering principles to address environmental and sustainability challenges. “I lead projects that transform degraded terrains into vibrant, functioning landscapes through bio-intelligent design, essentially converting ecological liabilities into assets. These systems are in many cases designed from microscopic level into mega supercell systems. We've developed over 20 conservation blueprints that integrate these principles at a landscape level, also preparing them for biodiversity financing.”

By founding and institutionalising the Ecological Engineering Institute of Africa (EEIA), the EEIA aims to spread this innovative approach, emphasising the importance of both scientific rigour and ecological viability continent-wide in Africa. The goal is to create sustainable, economically sound, and ecologically robust solutions that not only regenerate but enhance environmental health and resilience for the benefit of ecosystems and communities.

Addressing water challenges in South Africa

Dr Bimo Nkhata sees his nomination as a personal milestone and as a reflection of the importance of the work he is doing to address water challenges in South Africa. The nomination also reinforces his commitment to the cause, and inspires him to strive for even greater achievements in the future, he says.

“My research and work on sustainable water management is of utmost importance for South Africa because the country faces significant water quality challenges due to pollution from various sources, including agriculture, industry, and urbanisation. Sustainable water management practices ensure the availability of sufficient and clean water for various sectors, supporting economic growth, job creation, and poverty alleviation.

“My research and initiatives contribute to protecting and preserving the country’s precious water resources, ensuring they remain clean and safe for both human consumption and ecosystem health,” explains Dr Nkhata.

Ensuring a sustainable future for the earth

For Prof Steenhuisen, this nomination is a humbling experience which will go a long way to highlighting her research group’s research.

“This nomination was certainly not earned alone; I have a fantastic collaborative support team being recognised for all the late nights and monumental efforts of the team is a huge privilege and honour. It will hopefully attract funders and interest to further support our project needs,” she says.

According to her, their research team, dubbed the QPAIR lab for Qwaqwa Plant-Animal Interactions Research lab, investigates the dynamics of mountain ecosystems in terms of pollination, seed dispersal and other aspects of plant reproductive ecology and vegetation community, largely assessing the impacts of climate change and invasive alien plants on these systems.

Prof Steenhuisen says everyone should be working towards ensuring a sustainable future for the earth in terms of conservation of biodiversity and ecosystem services that can lead to food security, resilient ecosystems and healthy human livelihoods. Climate change, the loss of biodiversity due to land degradation and the spread of invasive alien species threaten these services and especially sensitive systems such as those found in our mountains. 

• The awards ceremony will take place on 11 July 2024.

News Archive

Institutional research culture a precondition for research capacity building and excellence
2004-11-16

A lecture presented by Dr. Andrew M. Kaniki at the University of the Free State Recognition Function for research excellence

16 November 2004
The Vice Chancellor, Prof. Frederick Fourie
Deputy Vice Chancellors, Deans
Awardees
Colleagues and ladies and gentlemen

It is a great pleasure to be here at the University of the Free State. I am particularly honoured to have been invited to present this lecture at the First Annual Recognition Function for Research Excellence to honour researchers who have excelled in their respective fields of expertise. I would like to sincerely thank the office of the Director of Research and Development (Professor Swanepol), and in particular Mr. Aldo Stroebel for facilitating the invitation to this celebration.

I would like to congratulate you (the UFS) for institutionalizing “celebration of research excellence”, which as I will argue in this lecture is one of the key characteristics of institutional research culture that supports research capacity building and sustains research excellence.

Allow me to also take this opportunity to congratulate the University of the Free State for clocking 100 years of existence.

Ahmed Bawa and Johan Mouton (2000) in their chapter entitled Research, in the book: Transformation in higher education: global pressures and local realities in South Africa (ed. N. Cloete et. al Pretoria: CHET. 296-333) have argued that “…the sources of productivity and competitiveness [in the knowledge society and global economy] are increasingly dependent on [quality] knowledge and information being applied to productivity”. The quality knowledge they refer to here is research output or research products and the research process, which (research) as defined by the [OECD] Frascati Manual (2002: 30) is:

“…creative work undertaken on a systematic basis in order to increase the stock of knowledge, including knowledge of man, culture and society, and the use of this stock of knowledge to devise new applications”

The South African Government has set itself the objective of transforming South Africa into a knowledge society that competes effectively in the global system. A knowledge society requires appropriate numbers of educated and skilled people to create quality new knowledge and to translate the knowledge in innovative ways. To this end a number of policies and strategies like the Human Resource Development [HRD] Strategy for South Africa, the National Plan for Higher Education (NPHE) and the South Africa’s Research and Development [R&D] Strategy, have highlighted human resource development and the concomitant scarce skills development as critical for wealth creation in the context of globalization. The key mission of the HRD Strategy for instance is:

To maximize the potential of the people of South Africa, through the acquisition of knowledge and skills, to work productively and competitively in order to achieve a rising quality of life for all, and to set in place an operational plan, together with the necessary institutional arrangements, to achieve this.

The R&D Strategy emphasizes that maximum effort must be exerted to train the necessary numbers of our people in all fields required for development, running and management of modern economies. Higher education institutions like the University of the Free State have a key role to play in this process, because whatever form or shape a university takes, it is expected to conduct research (quality research); teach (quality teaching – and good graduates); and contribute to the development of its community! Thus the NPHE states that the role of higher education in a knowledge-driven world is threefold:

Human resource development;

High-level skills training and

Production, acquisition and application of knowledge.

Quality research output or knowledge which as argued is critical in determining the degree of competitiveness of a country in the knowledge economy is dependent upon quality research (process). Both the process of producing quality research and its utilization cannot and does not happen in a vacuum. It requires an environment that facilitates the production of new knowledge, its utilization and renewal. It requires skilled persons that can produce new knowledge and facilitate the production of new skills for quality knowledge production. Such an environment or in essence a university must have the culture that supports research activity. Institution research culture (that is a conducive and enabling institutional research culture) is a precondition to research capacity building. Without an institutional research culture that facilitates the development and nurturing of new young researchers it is difficult, if not impossible for a university to effectively and efficiently generate new and more quality researchers. Institutional research culture is also necessary to sustain quality research and quality research output or research excellence. It facilitates the development and sustenance of the institutional and people capacities required to do research produce quality research and generally attain research excellence!

We do recognize that the patterns of information and knowledge seeking, and knowledge generation vary among field or disciplines. For example, we know that in the humanities knowledge workers often work individually, and not as collaboratively as do those of the sciences, they all however, require supportive environments – institutional research culture to achieve and sustain research excellence. An institution does not simply attain a supportive research culture, but as Patricia Clements (English Department, University of Alberta, Edmonton) in her presentation Growing a research culture argues, research culture has to be grown [and maintained]. It unifies all natural and engineering scientists; medical researchers, humanists, and social scientists.

I therefore am of the view that Institutional Research Culture is critical to research capacity building and research excellence. I therefore want to spend a few minutes looking at the characteristics of research culture. To be effective, institutional research culture has grown and sustained not only at the institutional level, but also at the faculty, school and departmental levels of any university.

What is Research Culture?

In the process of researching on institutional research culture I identified several characteristics. Many of these overlap in some way. I want to deal with some of these characteristics; some in a little more detail while others simply cursorily. In the process what we should be asking ourselves is the extent to which an institution, like the University of the Free State, and its faculties, individually and severally, is growing and or sustaining this culture.

Institutional Research Strategy: As a plan of action or guide for a course of action, the institutional research strategy must spell out research goals that a university wants to achieve. It must be a prescription of what the university needs to be done with respect to research. As a strategy it is neither an independent activity nor an end in itself, but a component part and operationalization of the university policy or mission. ( Related to this is the Establishment of Institutional research policies)

Includes and makes public the targets, e.g. achieve so many rated scientists and make sure that every year we have so many SAPSE publications. That way people keep an eye on research agendas of the university and nation.

The UFS is obviously on its way, having launched its own Research strategy (A Strategic framework for the development of research at the University of the Free Sate. August 2003). Note that this strategy refers specifically to the “Culture of research” Fig 1

A set of administrative practices to support and encourage research. Patricia Clements (English Department, University of Alberta, Edmonton) in her presentation Growing a research culture argues that that research activity and output within the her Faculty (Arts) were very low and, in spite of the numbers of staff, with no Associate Dean for Research in the Faculty as though they had accepted that research belonged to Medicine and Science and Engineering, and teaching, separated from inquiry, belonged to the Arts. With the change in the thinking about research and development of research culture, it became clear that there was a major role for research support in a faculty her size (now about 360 full time continuing academic staff). The faculty developed a support system for research and began to address the SSHRC issues.

Reduce the bureaucracy system and micromanagement of research! This however, also implies that there is capacity and policies and procedure to manage and guide research processes

Establishment of Intellectual Property regulations and assistance

Research ethics policy and safeguarding by research administration

Focused, applied and suitable nature of the delivery mode (an institution open to new methodologies for conducting research

Programmes suited both full and part-time study particularly at graduate level (Mainly at Faculty/school and department level, and depending on what’s manageable)

Hiring senior academics to engage in, teach on and supervise postgraduate students to facilitate exchange of and transfer ideas and most importantly mentorship especially in view of declining numbers of researchers in particular fields

Quality instruction and facilitation in learning about research processes

A high retention rate of students maintained by the supportive and challenging learning environment and the use of online facilities to support collaboration and in-class learning

Availability of research grants: and awareness of sourcing funds from external sources like the National Research Foundation; Water Research Commission; Medical Research Council, private philanthropies and others outside the country. For example an institution should be able to assess how much of the slice the available funds (NRF etc) its able acquire and possibly top slice from institutional budget.

Adequacy of the financial reward system to encourage university staff members to do research (General Celebration of achievement for research excellence and achievement. This ranges form Annual reports mention; celebratory dinner. At Alberta researchers were given lapels. I don’t know of any academic who do not feel a sense of achievement to get into print or recognised. Access to research facilities within and outside the institution

Provision of infrastructure to support university-based research (e.g. equipment, admin support, etc.) – but also awareness of publicly funded and available research facilities and equipment!

Internet connectivity and changes in the bandwidth of the internet to download articles

Subscription to related bodies by the library so that researcher can download articles

Facilities and resources to attend international conferences to keep one updated

Number of visiting professors/speakers targeting senior scholars and invite them to lunch to ask them to participate and to encourage their best graduate students to do so within the institution and across institutions

Research training seminars for research students including young academics

Participation of staff/students in delivering research papers to national and international conferences

Establishment of research groups to provide interaction frameworks to achieve critical mass of research-active staff

Facilitation for more research time: Targeting new scholars and giving them reduced teaching loads in their first year or two for the purpose of developing their research programs. For the purpose of helping new colleagues to see the shape of South African research support, personalizing it, and creating research community

Take research to the community and argue its necessity, and utility

And, finally celebrating excellence. We must recognize achievement - parties and public recognition for colleagues who achieve splendid things in their research.

In conclusion, I want to reemphasize that research culture has to be grown it does not simply exist in an institution. If it is grown it needs to be nourished, nurtured and sustained. An institution cannot simply leave on borrowed reputation and expect to remain research excellent. It is on this basis that instruments like the National Research Foundation rating system recognizes excellence within a given period of time and not necessarily for a life time! This it is believed encourages continued research excellence.

THANK YOU and best wishes

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