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09 May 2024 | Story André Damons | Photo Supplied
Science Oscars Winners 2024
From top-left to right: Drs Claudia Ntsapi, Mpho Mafa, Angélique Lewies, Yolandi Schoeman, and Bimo Nkhata are dedicated to innovative solutions spanning from addressing brain aging to enhancing food security, developing xenograft scaffolds for regenerative medicine, transforming degraded terrains into vibrant landscapes, and protecting precious water resources. Prof Sandy-Lynn Steenhuisen's research team investigates the dynamics of mountain ecosystems in terms of pollination, seed dispersal and other aspects of plant reproductive ecology and vegetation community, largely assessing the impacts of climate change and invasive alien plants on these systems.

A neuropsychologist, a biochemist, a cell biologist, and an ecological engineer from the University of the Free State (UFS) have all received their first nomination in this year’s NSTF-South32 Awards. The four researchers have been nominated in the TW Kambule-NSTF Award: Emerging Researcher category.

These emerging researchers are part of a group of nine UFS researchers nominated for the ‘Science Oscars of South Africa’. Two other researchers; Prof Sandy-Lynn Steenhuisen, Associate Professor and Subject Head: Department of Plant Sciences and the Afromontane Research Unit (ARU), and Dr Bimo Abraham Nkhata, Senior Lecturer at the UFS Centre for Environmental Management (CEM), have also been nominated in the categories Green Economy and NSTF-Water Research Commission (WRC) respectively.

Preserving human brain health with age

Dr Claudia Ntsapi, who is passionate about exploring innovative solutions to address the gradual decline in normal brain function associated with aging, says the research that led to her nomination focuses on preserving human brain health to delay or prevent age-related conditions, such as Alzheimer's disease.

The nomination, she says, reaffirms the growing impact of their research efforts and reinforces her commitment to contributing toward enhancing the quality of life for individuals affected by age-related neurodegenerative diseases and their families.

“Leveraging advanced cell-based models that mimic human cellular environments, my research investigates the potential benefits of medicinal plants as supplementary treatments for neurodegenerative diseases. By utilising cutting-edge techniques, such as the innovative CelVivo ClinoStar 2 System, we strive to gain insights into the safety and efficacy of underexplored medicinal plants in preserving cognitive function and slowing disease progression.

“By exploring the untapped potential of bioactive compounds found in medicinal plants and nutraceuticals, our research group aims to contribute to the identification of novel therapeutic targets and the discovery of new avenues for intervention to improve the quality of life for individuals affected by age-related brain conditions,” Dr Ntsapi explains.

Improving food security, and renewable resources for circular economy 

A humbled and excited Dr Mpho Mafa says his nomination is based on the impact and quality of research his group (carbohydrates and enzymology Laboratory: CHEM-Lab) produced since 2020.

“My research group uses biochemical, enzymological, and biotechnological techniques to study the physiological and biochemical functions of carbohydrate-active enzymes (CAZymes) and carbohydrate metabolism during wheat interaction with rust disease-causing fungi or wheat infestation by a virulent Russian wheat aphid (RWA) biotype,” he said.

“The findings from these studies allow us to identify the key genes, enzymes, metabolites and biochemical processes used by wheat plants to reduce the effects of rust fungi or RWA damage, leading to improved plant health and yield. Thus, my research group uses innovative biochemistry/biotechnology approaches to protect the second-most important grain crop in South Africa against rust diseases and aphid attack.”

In addition, Dr Mafa uses the CAZymes in the field of lignocellulosic biorefinery to produce value-added products (VAPs), such as fermentable carbohydrates used in the production of second-generation biofuel for the circular economy. 

“I want to thank the NRF-Thuthuka for funding the lignocellulosic biorefinery project which aims to improve the conversion rate of lignocellulose to VAPs through enzymatic catalysis processes.” Dr Mafa says.

Tissue engineering and regenerative medicine

According to Dr Angélique Lewies, this achievement was truly a team effort from her dedicated colleagues at the Robert WM Frater Cardiovascular Research Centre. She says the nomination validates her team’s hard work and dedication, and recognises their efforts to advance the fields of tissue engineering and regenerative medicine.

“Our team has developed xenograft tissue scaffolds from non-human sources with a reduced potential to induce immune responses in human recipients, which are common causes of calcification, degradation, and failure of surgical scaffolds. We pioneered a processing technique that promotes cell infiltration, remodelling, and regeneration of the tissue. These xenografts are versatile, showing promise for use in various surgical disciplines, including cardiac and plastic surgery,” Dr Lewies says.

Induced pluripotent stem cells created from recipient skin cells, she explains, can be combined with the processed tissue, creating custom tissue products for improved patient-specific outcomes. Their research has successfully developed a method for processing bovine pericardium that not only mitigates calcification but also preserves mechanical properties and enhances host cell infiltration, significantly increasing the longevity of the tissue when used clinically.

Environmental and sustainability challenges

“This nomination is both an honour and an affirmation of the importance of ecological engineering in addressing today’s environmental challenges,” says Dr Yolandi Schoeman.

“It represents a recognition of the value and impact of integrating natural processes with engineering principles to create sustainable and resilient ecosystems whilst addressing some of our most pressing sustainability challenges,” Dr Schoeman says.

Her work primarily revolves around ecological engineering — a field that combines natural processes with engineering principles to address environmental and sustainability challenges. “I lead projects that transform degraded terrains into vibrant, functioning landscapes through bio-intelligent design, essentially converting ecological liabilities into assets. These systems are in many cases designed from microscopic level into mega supercell systems. We've developed over 20 conservation blueprints that integrate these principles at a landscape level, also preparing them for biodiversity financing.”

By founding and institutionalising the Ecological Engineering Institute of Africa (EEIA), the EEIA aims to spread this innovative approach, emphasising the importance of both scientific rigour and ecological viability continent-wide in Africa. The goal is to create sustainable, economically sound, and ecologically robust solutions that not only regenerate but enhance environmental health and resilience for the benefit of ecosystems and communities.

Addressing water challenges in South Africa

Dr Bimo Nkhata sees his nomination as a personal milestone and as a reflection of the importance of the work he is doing to address water challenges in South Africa. The nomination also reinforces his commitment to the cause, and inspires him to strive for even greater achievements in the future, he says.

“My research and work on sustainable water management is of utmost importance for South Africa because the country faces significant water quality challenges due to pollution from various sources, including agriculture, industry, and urbanisation. Sustainable water management practices ensure the availability of sufficient and clean water for various sectors, supporting economic growth, job creation, and poverty alleviation.

“My research and initiatives contribute to protecting and preserving the country’s precious water resources, ensuring they remain clean and safe for both human consumption and ecosystem health,” explains Dr Nkhata.

Ensuring a sustainable future for the earth

For Prof Steenhuisen, this nomination is a humbling experience which will go a long way to highlighting her research group’s research.

“This nomination was certainly not earned alone; I have a fantastic collaborative support team being recognised for all the late nights and monumental efforts of the team is a huge privilege and honour. It will hopefully attract funders and interest to further support our project needs,” she says.

According to her, their research team, dubbed the QPAIR lab for Qwaqwa Plant-Animal Interactions Research lab, investigates the dynamics of mountain ecosystems in terms of pollination, seed dispersal and other aspects of plant reproductive ecology and vegetation community, largely assessing the impacts of climate change and invasive alien plants on these systems.

Prof Steenhuisen says everyone should be working towards ensuring a sustainable future for the earth in terms of conservation of biodiversity and ecosystem services that can lead to food security, resilient ecosystems and healthy human livelihoods. Climate change, the loss of biodiversity due to land degradation and the spread of invasive alien species threaten these services and especially sensitive systems such as those found in our mountains. 

• The awards ceremony will take place on 11 July 2024.

News Archive

Media: ANC can learn a lesson from Moshoeshoe
2006-05-20


27/05/2006 20:32 - (SA) 
ANC can learn a lesson from Moshoeshoe
ON 2004, the University of the Free State turned 100 years old. As part of its centenary celebrations, the idea of the Moshoeshoe Memorial Lecture was mooted as part of another idea: to promote the study of the meaning of Moshoeshoe.

This lecture comes at a critical point in South Africa's still-new democracy. There are indications that the value of public engagement that Moshoeshoe prized highly through his lipitso [community gatherings], and now also a prized feature in our democracy, may be under serious threat. It is for this reason that I would like to dedicate this lecture to all those in our country and elsewhere who daily or weekly, or however frequently, have had the courage to express their considered opinions on pressing matters facing our society. They may be columnists, editors, commentators, artists of all kinds, academics and writers of letters to the editor, non-violent protesters with their placards and cartoonists who put a mirror in front of our eyes.

There is a remarkable story of how Moshoeshoe dealt with Mzilikazi, the aggressor who attacked Thaba Bosiu and failed. So when Mzilikazi retreated from Thaba Bosiu with a bruised ego after failing to take over the mountain, Moshoeshoe, in an unexpected turn of events, sent him cattle to return home bruised but grateful for the generosity of a victorious target of his aggression. At least he would not starve along the way. It was a devastating act of magnanimity which signalled a phenomenal role change.

"If only you had asked," Moshoeshoe seemed to be saying, "I could have given you some cattle. Have them anyway."

It was impossible for Mzilikazi not to have felt ashamed. At the same time, he could still present himself to his people as one who was so feared that even in defeat he was given cattle. At any rate, he never returned.

I look at our situation in South Africa and find that the wisdom of Moshoeshoe's method produced one of the defining moments that led to South Africa's momentous transition to democracy. Part of Nelson Mandela's legacy is precisely this: what I have called counter-intuitive leadership and the immense possibilities it offers for re-imagining whole societies.

A number of events in the past 12 months have made me wonder whether we are faced with a new situation that may have arisen. An increasing number of highly intelligent, sensitive and highly committed South Africans across the class, racial and cultural spectrum confess to feeling uncertain and vulnerable as never before since 1994. When indomitable optimists confess to having a sense of things unhinging, the misery of anxiety spreads. It must have something to do with an accumulation of events that convey the sense of impending implosion. It is the sense that events are spiralling out of control and no one among the leadership of the country seems to have a handle on things.

I should mention the one event that has dominated the national scene continuously for many months now. It is, of course, the trying events around the recent trial and acquittal of Jacob Zuma. The aftermath continues to dominate the news and public discourse. What, really, have we learnt or are learning from it all? It is probably too early to tell. Yet the drama seems far from over, promising to keep us all without relief, and in a state of anguish. It seems poised to reveal more faultlines in our national life than answers and solutions.

We need a mechanism that will affirm the different positions of the contestants validating their honesty in a way that will give the public confidence that real solutions are possible. It is this kind of openness, which never comes easily, that leads to breakthrough solutions, of the kind Moshoeshoe's wisdom symbolises.

Who will take this courageous step? What is clear is that a complex democracy like South Africa's cannot survive a single authority. Only multiple authorities within a constitutional framework have a real chance. I want to press this matter further.

Could it be that part of the problem is that we are unable to deal with the notion of "opposition". We are horrified that any of us could become "the opposition". In reality, it is time we began to anticipate the arrival of a moment when there was no longer a single [overwhelmingly] dominant political force as is currently the case. Such is the course of change. The measure of the maturity of the current political environment will be in how it can create conditions that anticipate that moment rather than ones that seek to prevent it. This is the formidable challenge of a popular post-apartheid political movement.

Can it conceptually anticipate a future when it is no longer overwhelmingly in control, in the form in which it currently is and resist, counter-intuitively, the temptation to prevent such an eventuality? Successfully resisting such an option would enable its current vision and its ultimate legacy to our country to manifest itself in different articulations of itself, which then contend for social influence.

In this way, the vision never really dies, it simply evolves into higher, more complex forms of itself. If the resulting versions are what is called "the opposition" that should not be such a bad thing - unless we want to invent another name for it. The image of flying ants going off to start other similar settlements is not so inappropriate.

I do not wish to suggest that the nuptial flights of the alliance partners are about to occur: only that it is a mark of leadership foresight to anticipate them conceptually. Any political movement that has visions of itself as a perpetual entity should look at the compelling evidence of history. Few have survived those defining moments when they should have been more elastic, and that because they were not, did not live to see the next day.

I believe we may have reached a moment not fundamentally different from the sobering, yet uplifting and vision-making, nation-building realities that led to Kempton Park in the early 1990s. The difference between then and now is that the black majority is not facing white compatriots across the negotiating table. Rather, it is facing itself: perhaps really for the first time since 1994. It is not a time for repeating old platitudes. Could we apply to ourselves the same degree of inventiveness and rigorous negotiation we displayed up to the adoption or our Constitution?

Morena Moshoeshoe faced similarly formative challenges. He seems to have been a great listener. No problem was too insignificant that it could not be addressed. He seems to have networked actively across the spectrum of society. He seems to have kept a close eye on the world beyond Lesotho, forming strong friendships and alliances, weighing his options constantly. He seems to have had patience and forbearance. He had tons of data before him before he could propose the unexpected. He tells us across the years that moments of renewal demand no less.

  • This is an editied version of the inaugural Moshoeshoe Memorial Lecture presented by Univeristy of Cape Town vice-chancellor Professor Ndebele at the University of the Free State on Thursday. Perspectives on Leadership Challenges In South Africa

 

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