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18 November 2024 | Story Nicolle Loader and Rudi Swart | Photo Supplied
Centre for Mineral Biogeochemistry
The team from the UFS who assisted with the Tritech National Science and Technology Fair. Back, from left, Prof Johan Venter, Dr Ernie Langner, Dr Litheko Nkabiti, Dr Rudi Swart, all from the Department of Chemistry; Vuyelwa Nkoi, Department of Sustainable Food Systems and Development; Dr Mariana Erasmus and Ouma Ngoepe from the CMBG. Front, from left, Khezwo Nematshema, Department of Sustainable Food Systems and Development; Dr Dumisani Kama, Department from Chemistry; Muhammad Sallie, CMBG; Shahiëda Cloete, SFSD; Nicolle Loader, CMBG; and Mellisa Pringle (Lasec)

The Centre for Mineral Biogeochemistry (CMBG) at the University of the Free State’s (UFS) support and partnership of the Tritech National Science and Technology Fair reached new heights this year with the event set to be featured in a new television series.

CMBG has been a proud sponsor and partner of the Tritech National Science and Technology Fair for the past four years. Established in 2008, Tritech is a renowned competition that allows Grade 7 to Grade 12 learners from across South Africa to showcase their research abilities. The Tritech National Science Competition serves as a beacon of opportunity for young minds, fostering their passion for scientific exploration and igniting their curiosity. It is designed to enhance scientific literacy, encourage innovation, and nurture the next generation of scientists and inventors.

“The CMBG has consistently demonstrated its commitment to promoting education and empowering young individuals. As a result, we have partnered with Tritech since 2021, and I believe that this partnership has opened new doors and possibilities for our young scientists. We are incredibly honoured to be part of such a dynamic and inspiring environment,” said Dr Mariana Erasmus, Vice Director: CMBG and Tritech EXCO member.

Power of science and technology

According to Dr Erasmus, at the CMBG, they believe in the power of science and technology to transform our world. Their involvement in this event aligns perfectly with the centre’s commitment to fostering innovation, encouraging critical thinking, and nurturing the next generation of scientists and innovators.

“We are excited about the opportunities Tritech presents to the university to engage with cutting-edge projects, to exchange ideas, and build lasting collaborations. The spirit of curiosity and exploration that Tritech embodies is exactly what drives our institution’s mission forward.”

In addition to assisting with the judging of projects during the National Science Competition at the Merensky Agricultural Academy in Tzaneen, the CMBG presents a fun but intellectually stimulating activity, showcasing various STEM-related disciplines that UFS offers to inspire students from across South Africa to celebrate scientific discovery. Each year, the CMBG collaborates with a different department for these activities, and this year, in October 2024, the collaboration was with the UFS Department of Chemistry.

‘Science Olympics’

The theme for Tritech 2024 was “Science Olympics”, and after the formalities of the project presentations were completed, the fair kicked off with a grand procession led by bearers of flaming torches and flags reminiscent of Olympic ceremonies. “Learners marched proudly, symbolising their commitment to science, with representatives from UFS and Tritech EXCO leading the way, an unforgettable visual display honoured the learners’ passion for exploration,” said Dr Erasmus.

The event transitioned into a video presentation explaining the misuse of performance-enhancing drugs in sports, followed by interactive activities focused on analysing possible doping agents. Thereafter, the UFS team guided learners through hands-on experiments, demonstrating the science behind identifying performance-enhancing drugs. Through engaging, real-world applications, learners were not only able to detect these substances but quantify their findings, making the learning experience both fun and educational.

As the night closed, the Chemistry team mesmerised the audience with a ‘magic show’. Explosions of colour, booming sounds, and flashes of light filled the sky, leaving everyone in awe. The show combined entertainment and chemistry, showcasing the wonders of science through spectacular reactions.

On TV

The fair concluded the next day with activities like kart building and livestock showcases, ending with a prize-giving ceremony to reward the learners for their hard work throughout the year. Adding to the excitement, the event is set to be featured in a new television series, with the pilot episode filmed during the weekend of Tritech Nationals 2024.

“The series promises to bring the Tritech experience to life for a wider audience, aiming to capture the incredible spirit, creativity, and innovation that defines Tritech. It will be an incredible opportunity to gain recognition, inspire others, and highlight the importance of science and technology in solving real-world challenges,” Dr Erasmus concluded.

This year’s fair was a celebration of knowledge, creativity, and the endless possibilities of science, leaving a lasting impact on all who attended.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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