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18 November 2024 | Story Nicolle Loader and Rudi Swart | Photo Supplied
Centre for Mineral Biogeochemistry
The team from the UFS who assisted with the Tritech National Science and Technology Fair. Back, from left, Prof Johan Venter, Dr Ernie Langner, Dr Litheko Nkabiti, Dr Rudi Swart, all from the Department of Chemistry; Vuyelwa Nkoi, Department of Sustainable Food Systems and Development; Dr Mariana Erasmus and Ouma Ngoepe from the CMBG. Front, from left, Khezwo Nematshema, Department of Sustainable Food Systems and Development; Dr Dumisani Kama, Department from Chemistry; Muhammad Sallie, CMBG; Shahiëda Cloete, SFSD; Nicolle Loader, CMBG; and Mellisa Pringle (Lasec)

The Centre for Mineral Biogeochemistry (CMBG) at the University of the Free State’s (UFS) support and partnership of the Tritech National Science and Technology Fair reached new heights this year with the event set to be featured in a new television series.

CMBG has been a proud sponsor and partner of the Tritech National Science and Technology Fair for the past four years. Established in 2008, Tritech is a renowned competition that allows Grade 7 to Grade 12 learners from across South Africa to showcase their research abilities. The Tritech National Science Competition serves as a beacon of opportunity for young minds, fostering their passion for scientific exploration and igniting their curiosity. It is designed to enhance scientific literacy, encourage innovation, and nurture the next generation of scientists and inventors.

“The CMBG has consistently demonstrated its commitment to promoting education and empowering young individuals. As a result, we have partnered with Tritech since 2021, and I believe that this partnership has opened new doors and possibilities for our young scientists. We are incredibly honoured to be part of such a dynamic and inspiring environment,” said Dr Mariana Erasmus, Vice Director: CMBG and Tritech EXCO member.

Power of science and technology

According to Dr Erasmus, at the CMBG, they believe in the power of science and technology to transform our world. Their involvement in this event aligns perfectly with the centre’s commitment to fostering innovation, encouraging critical thinking, and nurturing the next generation of scientists and innovators.

“We are excited about the opportunities Tritech presents to the university to engage with cutting-edge projects, to exchange ideas, and build lasting collaborations. The spirit of curiosity and exploration that Tritech embodies is exactly what drives our institution’s mission forward.”

In addition to assisting with the judging of projects during the National Science Competition at the Merensky Agricultural Academy in Tzaneen, the CMBG presents a fun but intellectually stimulating activity, showcasing various STEM-related disciplines that UFS offers to inspire students from across South Africa to celebrate scientific discovery. Each year, the CMBG collaborates with a different department for these activities, and this year, in October 2024, the collaboration was with the UFS Department of Chemistry.

‘Science Olympics’

The theme for Tritech 2024 was “Science Olympics”, and after the formalities of the project presentations were completed, the fair kicked off with a grand procession led by bearers of flaming torches and flags reminiscent of Olympic ceremonies. “Learners marched proudly, symbolising their commitment to science, with representatives from UFS and Tritech EXCO leading the way, an unforgettable visual display honoured the learners’ passion for exploration,” said Dr Erasmus.

The event transitioned into a video presentation explaining the misuse of performance-enhancing drugs in sports, followed by interactive activities focused on analysing possible doping agents. Thereafter, the UFS team guided learners through hands-on experiments, demonstrating the science behind identifying performance-enhancing drugs. Through engaging, real-world applications, learners were not only able to detect these substances but quantify their findings, making the learning experience both fun and educational.

As the night closed, the Chemistry team mesmerised the audience with a ‘magic show’. Explosions of colour, booming sounds, and flashes of light filled the sky, leaving everyone in awe. The show combined entertainment and chemistry, showcasing the wonders of science through spectacular reactions.

On TV

The fair concluded the next day with activities like kart building and livestock showcases, ending with a prize-giving ceremony to reward the learners for their hard work throughout the year. Adding to the excitement, the event is set to be featured in a new television series, with the pilot episode filmed during the weekend of Tritech Nationals 2024.

“The series promises to bring the Tritech experience to life for a wider audience, aiming to capture the incredible spirit, creativity, and innovation that defines Tritech. It will be an incredible opportunity to gain recognition, inspire others, and highlight the importance of science and technology in solving real-world challenges,” Dr Erasmus concluded.

This year’s fair was a celebration of knowledge, creativity, and the endless possibilities of science, leaving a lasting impact on all who attended.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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