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16 September 2024 | Story André Damons | Photo Supplied
Dr Mampoi Jonas and Prof Jan Du Plessis
Dr Mampoi Jonas, senior lecturer in Paediatric Oncology and Prof Jan Du Plessis, Head of the Paediatric Oncology Unit at the University of the Free State (UFS).

A campaign like Childhood Cancer Awareness Month is vital in creating awareness and educating people about the early signs and symptoms of certain cancers. This can significantly improve the survival rate of young patients. More than 50% of people diagnosed with cancer live for more than five years, and some types of cancer have survival rates as high as 90%.

This is according to Prof Jan Du Plessis, Head of the Paediatric Oncology Unit, and Dr Mampoi Jonas, senior lecturer in Paediatric Oncology, at the University of the Free State (UFS).

“Early diagnosis is crucial because early-stage cancer is more responsive to treatment and less likely to be fatal. Due to the rarity of childhood cancer, many children get misdiagnosed or diagnosed too late with advanced stage disease. The delayed detection and diagnosis diminish the chances of successful treatment.

“Cancer awareness educates families, communities, primary-care nurses and doctors about the early signs and symptoms of certain cancers. When people are aware of these, they are more likely to be on the lookout for them when children present with suspicious clinical symptoms and signs. This also gives parents the confidence to seek help early and even make people better able to support those with the disease once a diagnosis is made,” say the paediatric oncologists.

Recorded incidences on the rise

Though childhood cancer is rare, representing only 1.2% of all cancers worldwide, the recorded incidences are increasing. In the US cancer is the number one cause of death among children, while more than 100 000 children worldwide die because of cancer.

Prof Du Plessis says there are more than 12 major types of childhood cancers and multiple subtypes. The most common types are leukaemia, lymphoma (tumours that begin in the lymph glands), brain tumours, nephroblastoma (cancer of the kidneys) and soft tissue sarcomas. Most cancers in children are thought to develop as a result of mutations in genes that lead to uncontrolled cell growth and eventually cancer.

According to Dr Jonas, most cancers in children are thought to develop because of mutations in genes that lead to uncontrolled cell growth and eventually cancer. Although environmental pollutants have been implicated in some cancers, our experience has been that most paediatric cancers rather occur sporadically.

The reasons for the increase of reported incidence of cancer in children, could be to the increase in population numbers and better awareness of childhood cancers. Another reason might be that more children are being diagnosed who were previously misdiagnosed, explains Prof Du Plessis.

Treatments

Childhood cancers are treated with chemotherapy, surgery and radiation therapy under the care of a paediatric oncologist. Not much can be done about the genetic mutations, but parents can ensure that their children stay safe in the sun (slip, slop, slap campaign – slip on a shirt, slop on some suncream and slap on a hat), get their children vaccinated against HPV infection, help their children stay active and keep a healthy weight and talk to them about smoking.

Prof Du Plessis says the South African paediatric oncology community are currently busy with a few research studies regarding standardising treatment protocols for certain childhood cancers. This is to find out how our children are responding to these protocols and to see if there are different factors affecting the outcomes of South African children. These protocols are based on international treatment protocols with a few adjustments for local circumstances and resources.

They are involved with the Hodgkins lymphoma, neuroblastoma, retinoblastoma, germ cell tumour studies and contributed to a research study evaluating the nutritional status and interventions to improve the nutritional status of local patients. Registrars presented local (Bloemfontein) data at an international conference (SIOP Africa) on hepatoblastomas and osteosarcomas.

“For many childhood cancer may not be a priority or something they would like to think about. Unfortunately for many of my patient’s parents the truth is that the day before their children were diagnosed with cancer, they were also not a cancer parent. However, their lives changed for ever with these four words: ‘Your child has cancer’.

“Childhood cancer is more than chemo and no hair. It is rather about resilience, strength, hope, family, courage, cuddles, and bravery. Your life will be changed for ever if you have ever seen a child fight cancer. Their smiles will make your heart melt and make you realise the importance of the simple things in life,” declare Prof Du Plessis and Dr Jonas.

Early warning signs for parents

The Childhood Cancer Foundation South Africa (CHOC) has a campaign which emphasises the importance of recognising the early warning signs of childhood cancer. They use Siluan’s Early Warning Signs to raise awareness and promote early diagnosis which are:

• S – Seek medical help early for ongoing symptoms
• I – White spot in the eye, new squint, sudden blindness or bulging eyeball.
• L – Lump on the stomach, pelvis, head, arms, legs, testicle, or glands
• U – Unexplained fever present for over two weeks, weight loss, fatigue, pale appearance, easy bruising, and bleeding
• A – Aching bones, joints, back, and easy fractures

• N – Neurological signs, a change in walk, balance or speech, regression, continuous headaches with/without vomiting, and an enlarged head

While these symptoms can be subtle or easily attributed to other causes, it’s important to consult a doctor if they persist or worsen. If you notice any of these symptoms in a child or teen, seek professional medical help promptly. Early detection of cancer saves lives in both children and teens.

News Archive

Einstein's gravitational waves as creative as Bach's music, says UFS physicist
2016-02-19

Description: Gravitational waves  Tags: Gravitational waves

Profile of the gravitational waves of the colliding black holes.

Prof Pieter Meintjes, Affiliated Researcher in the Department of Physics at the University of the Free State, welcomed the work done by the Laser Interferometer Gravitational-Wave Observatory (LIGO) science team.
 
For the first time, researchers from two of the American Ligo centres, in Washington and Louisiana respectively, observed gravitational waves directly, 100 years after Albert Einstein said they existed. "My study field in astrophysics involves relativistic systems. Therefore, Einstein's view of gravity is crucial to me. I consider the theory as the highest form of human creativity - just like the music of JS Bach. Over the past 100 years, the theory has been tested through various experiments and in different ways.
 
“The discovery of gravitational waves was the last hurdle to overcome in making this absolutely unfaltering. I am therefore thrilled by the discovery. It is absolutely astounding to imagine that the equations used to make the predictions about the gravitational-wave emissions when two gravitational whirlpools collide - as discovered on 14 September 2015 by LIGO - are basically Einstein's original equations that were published way back in 1916 - in other words, 100 years ago.
 
“The LIGO detectors have been operational since the early 1990s, but they had to undergo several stages of upgrades before being sensitive enough to make detections. LIGO is currently in its final stage, and is expected to function at optimal sensitivity only within a year or two. To be able to conduct the measurements at this stage is therefore a fantastic achievement, since much more funding will certainly be deposited in the project,” Prof Meintjes says.

Description: Prof Pieter Meintjes Tags: Prof Pieter Meintjes

Prof Pieter Meintjes
Photo: Charl Devenish

The search for gravitational waves by means of the Square Kilometre Array (SKA) is one of the focus points in research by both Prof Meintjes and PhD student, Jacques Maritz. This involves the study of radio signals from pulsars that might show signs of effects by gravitational waves. They are looking for signs of gravitational waves. The gravitational waves discovered and studied in this manner would naturally vary much more slowly than the signal discovered from the two colliding gravitational waves.
 
The discovery will definitely provide renewed impetus to the Square Kilometre Array (SKA) Project to use the dispersion of pulsar signals, and to search for the impact of gravitational waves on signals as they travel through the universe. According to Prof Meintjes, the SKA will definitely contribute fundamentally to the Frontier research, which will provide a good deal of publicity for the UFS and South Africa, if significant contributions are made by local researchers in this field.

Video clip explaining gravitational waves

 

  • The Department of Physics will present a general, non-technical talk concerning the recent detection of gravitational waves by the 2 Laser Interferometer Gravitational Wave Observatories (LIGO):

Wednesday 24 February 2016
11:00-12:00
New lecture auditorium, Department of Physics

 

 

 

 

 

 

 

 

 

 

 

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