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UFS on track to revolutionise student success and boost sustainability

14 August 2025 | Story Onthatile Tikoe and the Centre for Teaching and Learning | Photo Supplied

CTL — From the left: Dr Jenny Glennie (SAIDE), Gugu Khanye (Director: Student Success – UFS), Prof Matete Madiba (Deputy Vice-Chancellor – UWC), Prof Francois Strydom (UFS Siyaphumelela Lead), and Prof Nthabiseng Ogude (Siyaphumelela Institutional Coach) at the 2025 Siyaphumelela Conference. The group played a key role in advancing conversations around student success, collaboration, and innovation in higher education.

The University of the Free State (UFS) is advancing a transformative approach to student success that positions it to become a national leader in enhancing social mobility. This vision was underscored at the 2025 Siyaphumelela Conference, where the university shared details of its groundbreaking collaboration with the National Institute for Student Success (NISS) at Georgia State University (GSU) in the United States.

Prof Francois Strydom, Senior Director: Centre for Teaching and Learning (CTL), explained that the initiative builds on lessons from GSU’s remarkable achievements. “The success of Georgia State University has been truly inspiring,” he said. “The NISS approach, which focuses on using data to dismantle systemic barriers and improve graduation rates, has transformed outcomes for a predominantly low-income and diverse student body. By contextualising this data-driven model for our environment, the UFS is proud to be the first university on the African continent to implement it.”

Building on proven success

GSU’s success in eliminating equity gaps in retention and completion among different racial groups was achieved through a redesign of its support structures and processes. Drawing on its own established track record of narrowing equity gaps in success rates, the UFS aims to replicate these outcomes in a way that is tailored to its unique context.

At the conference, the UFS Centre for Teaching and Learning (CTL) launched a new national report on student engagement trends and presented papers on a range of topics. These included innovative strategies for improving performance in high-priority modules, the use of predictive analytics to provide proactive student support, and research into gender differences in academic performance and class attendance in a post-COVID world.

Prof Strydom also led an exploratory panel discussion on strengthening collaboration between universities, business, and philanthropy to drive large-scale student success initiatives. “By facilitating a deeper understanding between philanthropic organisations, businesses, and universities, we can develop innovative and impactful approaches to funding and student support,” he said.

Driving innovation and sustainability

The UFS’ contributions at the conference were further reinforced by institutional projects focused on the evidence-based integration of artificial intelligence (AI) into student learning and success. These initiatives reflect a clear commitment to transformation that is both research-led and data-driven.

Looking ahead, Prof Strydom emphasised the opportunity before the institution: “We have a unique opportunity to leverage the lessons learnt from our student success initiatives to guide further research, deploy technology in ways that optimise human connection, and help create responsible societal futures while contributing to the sustainability of our university.”

News Archive

UFS study on cell development in top international science journal

2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
18 September 2008

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