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19 August 2025 | Story Martinette Brits
Dr Tlou Raphela-Masuku
Dr Tlou Raphela-Masuku, Senior Lecturer in the UFS Disaster Management Training and Education Centre for Africa (DiMTEC), was selected as one of 15 early-career researchers from Southern and Eastern Africa to join the British Academy-funded International Writing Workshop on Climate Change Adaptation.

Dr Tlou Raphela-Masuku, Senior Lecturer in the University of the Free State (UFS) Disaster Management Training and Education Centre for Africa (DiMTEC), has been selected as one of only 15 early-career researchers from Southern and Eastern Africa to participate in the prestigious British Academy-funded International Writing Workshop on Climate Change Adaptation.

Her selection follows a highly competitive process involving applicants from across the region, underscoring her growing influence in climate research. “Being selected as one of only 15 early-career researchers from the SADC and East Africa region was truly humbling. It affirmed the value of my research and passion for climate adaptation and further motivated me to keep making a meaningful contribution in this field,” she said.

 

Strengthening research visibility and collaboration

The workshop is jointly organised by York St John University (UK), the University of the West of England (UK), the University of Nairobi (Kenya), and the University of Cape Town (South Africa). It brings together emerging scholars from a range of disciplinary backgrounds to foster interdisciplinary collaboration, strengthen academic writing and publishing skills, and develop grant proposal expertise.

For Dr Raphela-Masuku, the programme is a natural fit with her work at DiMTEC. “At DiMTEC, my work spans ecosystem-based disaster risk reduction and climate change adaptation. I am the core teacher for this module for master’s students. My recent and upcoming research, including work on flood risks and climate vulnerability among subsistence farmers, directly aligns with the themes of the workshop,” she explained.

Her focus within the programme will be on climate-induced vulnerabilities and resilience, particularly in rural and peri-urban communities, with a strong emphasis on extreme weather events and nature-based solutions. She looks forward to both the online and in-person engagements in Nairobi and Cape Town, which will run between 2025 and 2027. “These offer a fantastic opportunity for peer learning, mentorship, and deeper engagement with fellow climate researchers. Exchanging ideas face to face is always energising and often leads to lasting collaborations,” she said.

 

Advancing DiMTEC’s mission

Participation in the workshop will not only advance Dr Raphela-Masuku’s own academic profile but also strengthen DiMTEC’s regional and continental footprint. “My participation directly supports DiMTEC’s mission to build climate resilience and disaster preparedness across Africa. It strengthens our footprint in the region and facilitates collaboration with other institutions working on similar challenges, especially in rural vulnerability and adaptation,” she noted.

She sees the experience as a vital platform to amplify her work on flood resilience and the health impacts of climate change to audiences that include academics, policymakers, and practitioners. “The workshop will enhance the visibility of my work and provide the tools and strategies to navigate high-impact publishing, which is crucial for emerging African scholars,” she added.

Reflecting on her journey, Dr Raphela-Masuku said it has been “rooted in both academic enquiry and real-world impact”, driven by the urgent need to support vulnerable communities. Her advice to aspiring researchers is clear: “Stay curious. Stay rooted in the needs of your communities. And don’t be afraid to ask hard questions or chase ambitious goals. Climate adaptation research is not just about publishing papers – it’s about finding real solutions for real people.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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