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25 June 2025 | Story Dr Nitha Ramnath | Photo Lunga Luthuli
Dr Omololu Aluko
Dr Omololu Aluko, Senior Lecturer in the Department of Biostatistics advances health research and collaboration during prestigious fellowship at Ghent University, Belgium.

Dr Omololu Aluko, Senior Lecturer in the Department of Biostatistics in the Faculty of Health Sciences at the University of the Free State (UFS), recently completed a prestigious short research stay at Ghent University in Belgium. The fellowship, hosted in April 2025, was awarded through the highly competitive Africa Platform of Ghent University Association (GAP) funding scheme, with additional support from the UFS International Office. 

A recognised expert in infectious disease modelling, particularly HIV/AIDS research in low-resource settings, Dr Aluko has devoted his academic career to using biostatistics to address pressing health challenges. His selection for this fellowship marks a significant achievement both for his individual research trajectory and for the broader ambitions of the Faculty of Health Sciences and the UFS.

 

Strategic steps towards international collaboration 

The opportunity for the fellowship was first announced in the UFS Digest Newsletter. Motivated by the potential for international collaboration, Dr Aluko began seeking a host at Ghent University whose interests aligned with his own. After several weeks of correspondence with various departments and researchers, a suitable academic collaborator agreed to host him. 

With a host confirmed, Dr Aluko submitted his application, which underwent a rigorous review and selection process. His proposal was shortlisted and ultimately approved. While Ghent University provided partial funding, supplementary financial support was secured through the UFS International Office. Dr Aluko credits the office’s assistance – especially the guidance of Mr Kagiso Ngake, Senior Officer: Partnerships – for helping him successfully secure the necessary resources. 

 

Advancing research in health data science  

During his time at Ghent University, Dr Aluko focused on the application of machine learning algorithms to address public health challenges – an increasingly important field within the Faculty of Health Sciences. His research demonstrated how advanced data analysis techniques can improve health outcomes and optimise treatment strategies, especially in resource-constrained settings. 

Beyond the immediate research achievements, the fellowship laid a foundation for long-term collaboration between the UFS and Ghent University. Key outcomes include: 

  • Opportunities for joint PhD supervision, allowing UFS students to conduct part of their research at Ghent University 
  • Prospects for publishing collaborative research in leading international A1-rated journals 
  • The identification of a promising young research collaborator, paving the way for future academic partnerships 
  • Plans to explore future staff exchange programmes, as new funding calls are announced 

     

A growing partnership in a new academic field 

Dr Annelies Verdoolaege, Coordinator for the Africa Platform at Ghent University, emphasised the broader vision behind the initiative:

“The purpose of these fellowships is to foster structural academic collaboration between Ghent University and partners in Africa. We offer a dedicated amount of seed funding to support short-term mobility, with the aim of building long-term partnerships – through student exchange, joint PhDs, joint funding proposals, and collaborative research publications. 

The UFS is a long-standing partner of Ghent University, especially in Education, Linguistics, and Agriculture. We are delighted that this fellowship has taken place in the field of Data Analysis and Mathematical Modelling - a scientific domain still to be fully developed between our institutions.” 

 

Enhancing UFS’ global research impact 

Dr Aluko’s successful fellowship reflects the high calibre of researchers at the UFS and illustrates the importance of international academic mobility. By securing this competitive opportunity, Dr Aluko not only advanced his own work but also strengthened the UFS’ global research footprint - opening new collaborative avenues and reinforcing the university's growing reputation in health sciences and data-driven research. 

The UFS expresses its sincere gratitude to the Africa Platform of Ghent University and the UFS International Office for their critical support in enabling this milestone. Partnerships such as this are key to fulfilling the UFS’ mission of producing world-class research and fostering meaningful global engagement. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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