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20 March 2025 | Story Andre Damons | Photo Andre Damons
Dr Willem Daffue
Dr Willem Daffue, veterinarian, adventurer, explorer, and conservationist, delivered the first plenary keynote address on the first day of the Southern African Mountain Conference (SAMC2025).

Africa’s mountains are being destroyed – not by global warming, but by small-scale farming caused by overpopulation on the continent.

This is according to Dr Willem Daffue, veterinarian, adventurer, explorer, and conservationist who delivered the first plenary keynote address on the first day of the Southern African Mountain Conference (SAMC2025). The conference, which follows a highly successful first conference in 2022, is currently taking place at the Champagne Sports Resort. It ends on 20 March 2025.

Comparing photos that he took 40 years ago in Ethiopia and the Democratic Republic of the Congo with more recent photos, Dr Daffue painted a dire picture of the future of Africa’s mountains and the unique animals found there.

Overpopulation

Dr Daffue works for the Himalayan Wildlife Project, tracks bears in the Karakoram Mountains, documents and photographs endangered species on a global level – such as the Javan rhino and Sumatran rhino. He is also involved in the Giraffe Project of the University of the Free State (UFS).

“Global warming has not yet affected Africa’s mountains. The rainfall in these areas actually increased. So has the population. Humans are destroying the mountains. The small-scale farmers have caused the most destruction. The reason for this is overpopulation.”

“Overpopulation is forcing people to invade national parks where they start farming for survival. These people are poor, uneducated, and is dependent on aid. All the animals in these areas are critically endangered.”

In his presentation, Dr Daffue talked about the Erta Ale, an active basaltic shield volcano in the Afar region of northeastern Ethiopia, the Simien Mountains in northern Ethiopia, as well as the Bale Mountains in the highlands of Ethiopia – with unique animals exclusive to the areas, including the wild ass, baboons, beisa oryx, Soemmerring's gazelle, Walia ibex, the golden jackal, and the Simien wolf.

Endangered animals

“Almost all the animals found in Ethiopia are endangered. It is the total destruction of nature. Only 4% of all mammals are still wild animals. 96% off all mammals on earth are humans and domesticated animals, and 70% of all birds on earth are chickens.”

“So, we are going to lose it. We are already past a point where we could save some of the animals and nature; it is an emergency but if we wake up now, we might still have a few things to save,” said Dr Daffue.

The answer is to curb the population growth, to educate the people, and to lift them out of poverty. Which is extremely difficult to do.

According to Dr Daffue, a conference such as the SAMC is extremely important, as it brings together different role players, including academics, researchers, communities, and policy makers. It helps in making plans, sharing knowledge, and getting policies out to people, the decision makers.

The conference

The Southern African Mountain Conference – conceptualised by the UFS Afromontane Research Unit (ARU), the African Mountain Research Foundation (AMRF), and Global Mountain Safeguard Research (GLOMOS) as a joint initiative between Eurac Research and the UNU Institute for Environment and Human Security – is unique, as it seeks to integrate the science, policy, and practitioner sectors for sustainable interventions in Southern African mountains.

Southern African mountains comprise those situated south of the Congo Rainforest and Lake Rukwa and include the mountainous islands of the western Indian Ocean. Thus, SAMC2025 is targeting Angola, the Comoros, the Democratic Republic of the Congo (southern mountains), Eswatini, Lesotho, Madagascar, Malawi, Mauritius, Mozambique, Namibia, La Réunion, South Africa, southern Tanzania, Zambia, and Zimbabwe.

The SAMC series is implemented by The Peaks Foundation (a non-profit company). SAMC2025 is held under the patronage of UNESCO.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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