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15 May 2025 | Story Precious Shamase | Photo Teboho Mositi
From right to left : Prof Aliza le Roux, Dr Regret Sunge, Prof Jared McDonald and Dr Calvin Mudzingiri.

The University of the Free State Qwaqwa Campus is celebrating a significant boost to its academic and research standing with the recent achievement of National Research Foundation (NRF) ratings by several esteemed academics. These ratings not only recognise the individual accomplishments and impact of these researchers but also underscore the campus' commitment to Vision 130 and the university's overarching strategy for academic and research excellence.

The Deputy Vice-Chancellor: Research and Internationalisation, Prof Vasu Reddy, explained the ratings, saying, “Ratings embody high ideals and recognition of scientific merit and impact in a knowledge-intensive economy, aligned with the UFS’ aspirations.”

Prof Jared McDonald, Assistant Dean of the Faculty of The Humanities, Dr Calvin Mudzingiri, Assistant Dean of the Faculty of Economic and Management Sciences, and Prof Richard Ocaya from the Department of Physics have all been awarded C2 ratings, signifying that they are established researchers with considerable international recognition for the quality and impact of their research outputs. This level of recognition highlights their consistent contribution to their respective fields and positions them as key players within the global research landscape.

Building on this impressive achievement, Prof Aliza le Roux, Assistant Dean of the Faculty of Natural and Agricultural Sciences, has attained a C1 rating, indicating that she is a leading international researcher recognised for the high quality and impact of her recent research outputs. This prestigious rating stresses Prof Le Roux's significant contributions and her standing as a prominent figure in her area of expertise.

Adding to the growing cadre of research talent on the Qwaqwa Campus, Dr Nthatisi Nyembe, Lecturer in the Department of Zoology and Entomology, and Dr Victor Gwande – Senior Lecturer in the Department of History – have both received Y1 ratings. Dr Regret Sunge, Lecturer in the Department of Economics and Finance within the Faculty of Economic and Management Sciences, has received the NRF Y2 rating for the period 1 January 2025 to 31 December 2030. This rating is awarded to promising young researchers who have demonstrated the potential to establish themselves as researchers with strong international recognition within five years after obtaining their doctorates. These Y1 ratings signal a bright future for research on the campus, highlighting the emergence of a new generation of impactful scholars.

NRF ratings are a crucial benchmark within the South African academic and research sector. They provide a peer-review assessment of the quality and impact of researchers' work, lending credibility and prestige to both the individual and their institution. For academics, a strong NRF rating can enhance their research collaborations, funding opportunities, and overall academic standing. For the institution, a growing number of rated researchers reflects a vibrant research environment and contributes to its reputation as a leading centre of knowledge production.

These achievements align directly with the UFS' Vision 130, which aims to elevate the university's academic and research profile, fostering a culture of innovation and impactful scholarship. The success of these Qwaqwa Campus academics demonstrates the tangible progress being made towards realising this vision and strengthening the university's strategic goals in academic and research excellence.

The UFS is committed to nurturing and supporting its academics in their research endeavours. Initiatives such as the Future Professoriate Programme and the Emerging Scholars Advancement Programme (ESAP) play a vital role in providing mentorship, resources, and opportunities for academics to develop their research careers and achieve their full potential. The recent NRF ratings are a testament to the effectiveness of these support structures and the dedication of the academics on the Qwaqwa Campus.

The University of the Free State proudly celebrates the accomplishments of Prof McDonald, Dr Mudzingiri, Prof Ocaya, Prof Le Roux, Dr Nyembe, Dr Gwande, and Regret Sunge. Their success is a source of inspiration for the entire university community and reaffirms the Qwaqwa Campus' growing prominence as a hub of impactful research.

In his congratulatory remarks, Prof Reddy said: “Our colleagues’ ratings confirm their dedicated and sterling work in advancing research and innovation. It is commendable to also see academic leaders in professional support being beacons to inspire others.”

He further commented: “We value your hard work and determination. Congratulations, you make us proud as a university. You inspire us all to follow you and we support you in reaching our research-intensive goals. We are confident that your ratings will inspire you, personally and professionally – as well as other colleagues – to grow further. Your efforts will help us as we move to new heights,” Prof Reddy concluded.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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