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UFS-NGS UNIT engages high school learners in pioneering step toward a genomic education

06 May 2025 | Story Andre Damons | Photo Supplied

Prof Nyaga — Prof Martin Nyaga at the UFS-NGS Unit sequencing room giving a talk on the Illumina NextSeq 2000 with the P3 flow cell in hand.

The University of the Free State – Next Generation Sequencing (UFS-NGS) Unit hosted a pioneering scholarly engagement initiative for Grade 11 learners from nine secondary schools in Bloemfontein. The three-day event with the theme "Frontiers of Discovery: Illuminating the Impact of Genomics in Science outreach programme” marked the first comprehensive genomics science outreach initiative in the Faculty Health Sciences.

Coordinated by Prof Martin Nyaga, Head of the UFS-NGS Unit, the programme bridged the longstanding gap through practical NGS exposure and ignited a passion for Science, Technology, Engineering, and Mathematics (STEM) by inspiring the next generation of genomic innovators using combined interactive lectures, laboratory demonstrations, career talks, and hands-on workshops. This allowed learners to directly engage with cutting-edge scientific techniques and genomic technologies, especially the scientific and evolutionally impact of Polymerase Chain Reaction (PCR) and NGS.

The initiative engaged selected Grade 11 learners from the nine schools: Brebner, Ikaelelo and Vulamasango (day 1), Atlehang, Castle Bridge School and Kaelang (day 2) and Eunice, Navalsig, and Lekhulong (day 3).

“This outreach programme marks a significant milestone in community-based genomics education in South Africa by offering high school learners the opportunity to engage with modern genomic sciences before making career decisions. The initiative particularly aimed to nurture future scientists and diversify the country’s STEM talent pipeline.

“This historic programme bridged gaps in scientific literacy and diversity in the Free State and concluded each day with a genomics quiz competition, which tested the participant’s newly acquired knowledge/exposure and provided a fun competitive learning opportunity. Six quiz winners across the three days received special prizes, and all students were awarded certificates of participation,” says Prof Nyaga.

Hands-on exploration and NHLS virology laboratory tour

The training was held at the UFS-NGS Unit in the School of Biomedical Sciences and at the NHLS Virology laboratories, School of Pathology, Faculty of Health Sciences. Each attending secondary school was represented by five Grade 11 learners and a life science’s educator. Each day, 15 learners and three educators observed hands-on practicals, including DNA extraction, PCR, gel electrophoresis, and DNA library preparation for sequencing on platforms such as Illumina MiSeq and NextSeq 2000.

Guided by the UFS-NGS Unit’s team members; Dr Milton Mogotsi, Hlengiwe Sondlane, Mbali Ncube, Nkosazana Shange, Somila Nazo, Sesiyanda Maseko, Surprise Baloyi, Manyi Eyong and Mamello Maku, the learners were exposed to how DNA is extracted and visualised, how the PCR machine works and how DNA libraries are prepared and sequenced.

Furthermore, a guided laboratory tour of the Virology laboratories at the NHLS was provided by Khauhelo Mafa which offered the leaners the opportunity to observe, diagnostic and molecular workflows in action, resulting in a real-time glimpse into world-class medical research and diagnostics, fuelling curiosity about the role of advanced genomics science in disease control.

Inspiration through expert talks

The learners were also inspired by talks from Prof Chris Viljoen, Head of the School of Biomedical Sciences, Prof Zinhle Makatini, Associate Professor and Head of Division of Virology, School of Pathology, and Dr Claudia Ntsapi, Senior Lecturer and researcher in the Department of Basic Medical Sciences at the UFS. Prof Viljoen highlighted the role of science in transforming lives and improving life expectancy, while Prof Makatini gave candid reflections on her professional journey, particularly how she pursued Medical Virology through unwavering determination and excelled to become among the pioneer women specialists in the field in South Africa. Dr Ntsapi inspired the audience with her perseverance from her humble beginnings to earning a PhD in Neurophysiological Sciences against all odds.

The speakers also delivered compelling presentations on the applications of genomics in medicine (e.g.), personalised cancer treatments), public health (e.g.), tracking HIV and COVID-19), agriculture (e.g.), resilient crops), and environmental science (e.g.), ecosystem protection), which resonated well with the learners, educators and the UFS-NGS team. A presentation on diverse career options available at the UFS Faculty of Health Sciences was further provided by Angelique Carson-Porter, a UFS representative from the Department of Nutrition & Dietetics. Her talk on different career pathways in Health Sciences broaden the learners’ horizons, fostering future aspirations.

Dr Emmanuel Ogunbayo, Dr Mogotsi, Thabisa Mpaxa, Nkosazana Shange and Eyong Manyi shared their personal career journey to be at the UFS-NGS Unit, offering advice on academic experiences and opportunities within genomics, bioinformatics, and biotechnology, while answering scholarship queries.

“The career talk opened my eyes. I’m now aiming for a biotechnology degree!” said Neliswa Thwala, a learner from Navalsig CS/S.

Following the enthusiastic response and tangible outcomes of this programme, the UFS-NGS Unit is committed to expanding this initiative, with plans to introduce similar events to other schools and developing sustained mentorship opportunities for learners interested in pursuing genomics-related careers. The UFS-NGS Unit further invites interested partners, sponsors, and stakeholders to collaborate in future outreach and capacity-building programmes to continue bridging the genomics education gap in Africa.

Inspire the next generation

Prof. Nyaga’s closing remarks highlighted the learners’ potential to shape the ‘omics’ workforce and stated the intention of the organising committee to expand the mentorship programmes, fostering a vibrant STEM pipeline. “This initiative represents our vision to make genomics accessible and inspire the next generation of African scientists.”

The success of this programme was driven by the UFS-NGS Unit team and was supported by Distribution Platform in Omics (DIPLOMICS).

For more information about the UFS-NGS Unit or future outreach programmes, please visit our website. Further pictures from the event are also available via our website.

News Archive

Childhood obesity should be curbed early

2017-03-15

Description: Child obesity Tags: Child obesity

Serious intervention by parents is required to deal
with childhood obesity. Prof Louise van den Berg and
a group of final-year PhD students worked on a study
about the prevalence of obesity in six-year-olds in
South Africa.
Photo: Supplied

If your child is overweight when they start school at the age of six, unless you do something about it at that point, the indications are they are going to be overweight teenagers and obese adults. This is according to University of the Free State’s Prof Louise van den Berg.

Evidence has shown that overweight children and teenagers have a greater risk of developing lifestyle diseases such as type 2 diabetes, hypertension and cardiovascular disease later in life, and dying prematurely.

Obesity is a global pandemic rapidly spreading among adults and children, in developed and developing countries alike.

Dr Van den Berg worked with Keagan Di Ascenzo, Maryke Ferreira, Monja-Marie Kok, Anneke Lauwrens, all PhD students with the Department of Nutrition and Dietetics, to conduct the study. Their research found that children who are overweight by the time they turn six should be screened for weight problems.

Why six-year-olds?
Children who are overweight between the ages of two and five are five times more likely to be overweight when they are 12. There are two periods in a normal life cycle when the body makes new fat cells. The first is in the uterus and the second is around the age of six. The second phase lasts from the age of six to puberty.

The study assessed the prevalence of obesity in six-year-olds as part of a campaign in South Africa to raise awareness of the problem among parents and educators.

A total of 99 children were chosen from seven schools in Mangaung, the capital city of Free State. The schools were chosen from quintile four and five schools, which when measured by their own resources and economic circumstances, are well resourced and serve largely middle-class and wealthy communities.

The children’s weight, height and waist circumference were measured and used to calculate a body mass index score and waist-to-height ratio. Both these figures are good predictors for future lifestyle disease risks such as type 2 diabetes, hypertension and cardiovascular disease. A person with a good waist-to-height ratio can wrap a piece of string equal to their height around their waist at least twice.

When the children had a higher body mass index, they also had an increased waist to height ratio. The study found one in four children from the schools surveyed were overweight when they started primary school.

Nipping the fat in the bud
Although there are many factors that play a role in preventing childhood obesity, parents’ perceptions of their children’s weight play an important role. A recent study found that more than 50% of parents underestimate the weight of their obese children. These parents remain unaware of the risks their children face and are not motivated to take any action.

At least half of the parents whose children are overweight struggle to recognise their children’s weight problems fearing that they will be labelled or stigmatised. By the time they turn six overweight children should be referred to dieticians and nutritionists who are qualified to guide their parents in getting them to eat well and be more physically active at pre-primary and primary school.

The high prevalence of weight problems among six-year-olds found in this study is an urgent call to healthcare professionals to step up and empower parents, educators and children with the necessary skills for healthy dietary practices and adequate physical activity.

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