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22 October 2025 | Story Leonie Bolleurs | Photo Supplied
Giraffe Research Centre
The giraffe research programme and infrastructure facility at Amanzi Private Game Reserve marks the next phase in a research journey that has already placed the UFS at the forefront of giraffe science.

The University of the Free State (UFS) is taking wildlife research to new heights. On Wednesday 29 October 2025, the university will officially launch the giraffe research programme and infrastructure facility at the Amanzi Private Game Reserve near Brandfort – a first-of-its-kind in the world, dedicated to advancing local and international scientific collaboration in the study and conservation of giraffes.

The launch marks the next phase in a research journey that has already placed the UFS at the forefront of giraffe science. Over the past decade, a team of researchers, led by Prof Francois Deacon from the Department of Animal Science, has made significant contributions to understanding giraffe behaviour, physiology, and ecology. Building on pioneering work in reproductive technologies, endocrinology, anatomy, and disease, the new infrastructure combines on-site research laboratories with spacious, stress-free habitats. In this hands-on environment, veterinarians, scientists, and students can work closely with giraffes while promoting their welfare and supporting both local and international research projects.

Over the past seven years, his team has conducted 254 successful sedations and captures, carefully building the expertise needed for the next delicate step: the first embryo transfer in wild giraffes.

“This dedicated research facility will provide a safe and controlled environment where the world’s first giraffe embryo can develop and grow, and where we can collaborate to produce the science needed to turn the extinction of the giraffe around,” he explains. “The general public may not see the results immediately, but 20 years from now, what we are doing today will be vital in creating a biobank of viable giraffe embryos and calves that can be used in surrogate animals, supporting sustainable conservation practices for future generations.”

This programme will allow researchers to expand their understanding of the world’s tallest land mammal in ways that were not possible before. “From conducting sedation and sample collection to pioneering reproductive techniques such as semen preservation and embryo transfer, the facility provides an environment where we can study, among others, giraffe genetics, reproductive biology, and physiology; knowledge that is important for their conservation and survival,” says Prof Deacon. 

About 12 departments at the UFS are already involved in the research project in one way or another. This includes from the Department of Animal Science to the Departments of Zoology and Entomology, as well as Chemistry and even Information and Communication and Technology Services, which contributes to 3D-modelling, software, and monitoring of the animals. 

The project also offers opportunities for collaboration with conservation organisations and universities worldwide, positioning the UFS as a leading hub for giraffe and large-mammal research in Africa. Current partners who share Prof Deacon’s vision for giraffe conservation on the African continent include Save the Giraffes (a US-based NGO), Absolute Genetics, Ramsem, and the Kroonstad Animal Hospital.

Despite their towering presence on the African continent, giraffes are quietly disappearing. The International Union for Conservation of Nature (IUCN) lists them as Vulnerable, with populations declining by more than 40% over the past three decades. Today, fewer than 100 000 remain in the wild – a sobering reminder that their future is far from secure and that research excellence like this is key to ensure their survival.

“We have all the technology and all the expertise to make a change. Now is the time to bring about this change to secure the future of giraffes on this continent,” Prof Deacon concludes, emphasising the UFS’ commitment to sustainability, care, and conservation.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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