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21 October 2025 | Story André Damons | Photo André Damons
Nuclear Medicine
Smiling proudly are Dr Gerrit Engelbrecht, Head of the UFS Department of Nuclear Medicine, Dr Tebatso Tebeila, senior resident in the same department, and Prof Osayande Evbuomwan, Senior Lecturer and medical specialist in nuclear medicine in the Department of Nuclear Medicine, with the certificate indicating they are now a Clinical Theranostics Centre of Excellence.

The Department of Nuclear Medicine at the Universitas Academic Hospital (UAH) and the University of the Free State (UFS) have been certified as Clinical Theranostics Centers of Excellence from the International Centers for Precision Oncology Foundation (ICPO). The hospital now joins only two other centres in South Africa to achieve this prestigious recognition.

The certification followed a rigorous evaluation process by the ICPO Foundation, which assessed the department’s clinical standards, infrastructure, expertise, and commitment to advancing theranostics. The application and verification process was done by Dr Tebatso Tebeila, a senior resident at the department who has just passed her final exams. She was supported by Dr Gerrit Engelbrecht, Head of the UFS Department of Nuclear Medicine, in the process which included interviews with the ICPO accreditation and projects director Dr Marwa Hakkam. Dr Tebeila had also completed the ICPO short course in Radiomolecular Precision Oncology through the ICPO Academy of Theranostics.

The UAH Nuclear Medicine Department began theranostics activities about five years ago, particularly in neuroendocrine and prostate malignancies. Prof Osayande Evbuomwan, Senior Lecturer and medical specialist in nuclear medicine in the UFS Department of Nuclear Medicine, received training for this during his residency period and had completed a rigorous international training workshop organised by the International Atomic Energy Agency on theranostics, particularly in prostate cancer, neuroendocrine neoplasms and well differentiated thyroid cancer. Prof Evbuomwan passed all these training and skills down to the department. The certification was further strengthened by the installation of department’s new state-of-the-art digital PET/CT camera, placing it on par with similar academic departments in the country. The recognition was officially conferred during the ICPO Reception at the European Association of Nuclear Medicine Congress in Barcelona earlier this month.  

 

A milestone achievement

“Being granted this certification signifies international recognition of our hospital’s commitment to the highest clinical, academic, and ethical standards in theranostics. It confirms that our institution meets the global benchmarks for delivering precision oncology care that integrates diagnostics and therapy for personalised cancer management.

“For our department and the University of the Free State, this is a milestone achievement that highlights our leadership in nuclear medicine and molecular imaging. It strengthens our research and training capacity and also attracts residents who want to be trained in nuclear medicine. It also enhances collaboration with international partners and aligns with our mission to advance precision medicine in South Africa and beyond,” says Prof Evbuomwan.

Theranostics, he explains, is an aspect of nuclear medicine that involves the use of a tracer bound to a radioisotope that can specifically locate and image cancer cells with high precision, characterise them and determine how much radiation will get to them. Using the same tracer, but a different radioisotope for therapy, these cancer cells are targeted with high precision and destroyed. It could be so precise that it targets only the cancer, sparing most of the normal tissue and thus resulting in less serious side effects. It is an aspect of nuclear medicine that is bound to revolutionise cancer care.

Dr Gerrit Engelbrecht says as a department, they are honoured and deeply proud of this achievement as it reflects months of dedication, innovation, and teamwork. “It validates our commitment to excellence in improving patient care and academic advancement, and we are motivated to build on this success. We are also grateful to Dr Tebeila for her initiative, hard work, dedication and networking skills.

“We would like to thank the ICPO Foundation for this recognition and for its continued efforts to support theranostics in developing regions. We also acknowledge the hard work of our staff, and partners who made this possible. This milestone inspires us to continue driving innovation and equitable access to precision oncology in Bloemfontein, the Free State province and South Africa at large.”

 

Forefront of precision oncology 

According to Prof Evbuomwan, patients will also benefit from this certification as it translates to improved access to world-class, and evidence-based theranostic management. It means earlier diagnosis, more accurate therapy selection, and ultimately, better treatment outcomes and quality of life for those with some of these cancers. They strongly believe the patients in the Free State also deserve access to this management, as the world is now moving slowly into the era of personalised and precision medicine. The Universitas Academic Hospital is now among three centres in South Africa (Numeri in SBAH Pretoria and Umhlanga Molecular Imaging and Therapy Centre in Durban) to achieve this prestigious recognition, joining an international network of 46 centres, mostly located in low- and middle-income countries. This positions the UFS at the forefront of precision oncology on the African continent.

Prof Evbuomwan says they hope to use this new status to expand patient access to theranostic treatments, foster multidisciplinary collaborations within the Universitas academic circuit, and participate in global research initiatives through the ICPO Academy for Theranostics. Certifications like this, he continues, would also help to attract more staff and junior resident doctors to the facility. It will also help them train the next generation of nuclear medicine specialists and strengthen South Africa’s role in precision oncology. The ICPO will also offer direct assistance to the facility to achieve these objectives.

On her trip to the EANM Congress in Barcelona to receive the certificate and to attend the international congress, Dr Tebeila said it is always such an honour to attend international conferences and this year’s EANM was particularly invigorating with the latest scientific presentations in various theranostic applications by peers and well-known experts in the global nuclear medicine sphere. 

“The highlight was, of course, attending the annual Oncidium Foundation Ambassadors meeting and being part of the ICPO certification ceremony along with my counterparts from 23 other centres spanning Asia, Arab regions and Africa. 

“My wish is to see the UAH nuclear medicine department grow in leaps and bounds, epically in patient reach, clinical research with academic expansion and overall excellence in service delivery. This ICPO theranostics centre of excellence certification is only the beginning of what is to come.”

News Archive

Fight against Ebola virus requires more research
2014-10-22

 

Dr Abdon Atangana
Photo: Ifa Tshishonge
Dr Abdon Atangana, a postdoctoral researcher in the Institute for Groundwater Studies at the University of the Free State (UFS), wrote an article related to the Ebola virus: Modelling the Ebola haemorrhagic fever with the beta-derivative: Deathly infection disease in West African countries.

“The filoviruses belong to a virus family named filoviridae. This virus can cause unembellished haemorrhagic fever in humans and nonhuman monkeys. In literature, only two members of this virus family have been mentioned, namely the Marburg virus and the Ebola virus. However, so far only five species of the Ebola virus have been identified, including:  Ivory Coast, Sudan, Zaire, Reston and Bundibugyo.

“Among these families, the Ebola virus is the only member of the Zaire Ebola virus species and also the most dangerous, being responsible for the largest number of outbreaks.

“Ebola is an unusual, but fatal virus that causes bleeding inside and outside the body. As the virus spreads through the body, it damages the immune system and organs. Ultimately, it causes the blood-clotting levels in cells to drop. This leads to severe, uncontrollable bleeding.

Since all physical problems can be modelled via mathematical equation, Dr Atangana aimed in his research (the paper was published in BioMed Research International with impact factor 2.701) to analyse the spread of this deadly disease using mathematical equations. We shall propose a model underpinning the spread of this disease in a given Sub-Saharan African country,” he said.

The mathematical equations are used to predict the future behaviour of the disease, especially the spread of the disease among the targeted population. These mathematical equations are called differential equation and are only using the concept of rate of change over time.

However, there is several definitions for derivative, and the choice of the derivative used for such a model is very important, because the more accurate the model, the better results will be obtained.  The classical derivative describes the change of rate, but it is an approximation of the real velocity of the object under study. The beta derivative is the modification of the classical derivative that takes into account the time scale and also has a new parameter that can be considered as the fractional order.  

“I have used the beta derivative to model the spread of the fatal disease called Ebola, which has killed many people in the West African countries, including Nigeria, Sierra Leone, Guinea and Liberia, since December 2013,” he said.

The constructed mathematical equations were called Atangana’s Beta Ebola System of Equations (ABESE). “We did the investigation of the stable endemic points and presented the Eigen-Values using the Jacobian method. The homotopy decomposition method was used to solve the resulted system of equations. The convergence of the method was presented and some numerical simulations were done for different values of beta.

“The simulations showed that our model is more realistic for all betas less than 0.5.  The model revealed that, if there were no recovery precaution for a given population in a West African country, the entire population of that country would all die in a very short period of time, even if the total number of the infected population is very small.  In simple terms, the prediction revealed a fast spread of the virus among the targeted population. These results can be used to educate and inform people about the rapid spread of the deadly disease,” he said.

The spread of Ebola among people only occurs through direct contact with the blood or body fluids of a person after symptoms have developed. Body fluid that may contain the Ebola virus includes saliva, mucus, vomit, faeces, sweat, tears, breast milk, urine and semen. Entry points include the nose, mouth, eyes, open wounds, cuts and abrasions. Note should be taken that contact with objects contaminated by the virus, particularly needles and syringes, may also transmit the infection.

“Based on the predictions in this paper, we are calling on more research regarding this disease; in particular, we are calling on researchers to pay attention to finding an efficient cure or more effective prevention, to reduce the risk of contamination,” Dr Atangana said.


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