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21 October 2025 | Story André Damons | Photo André Damons
Nuclear Medicine
Smiling proudly are Dr Gerrit Engelbrecht, Head of the UFS Department of Nuclear Medicine, Dr Tebatso Tebeila, senior resident in the same department, and Prof Osayande Evbuomwan, Senior Lecturer and medical specialist in nuclear medicine in the Department of Nuclear Medicine, with the certificate indicating they are now a Clinical Theranostics Centre of Excellence.

The Department of Nuclear Medicine at the Universitas Academic Hospital (UAH) and the University of the Free State (UFS) have been certified as Clinical Theranostics Centers of Excellence from the International Centers for Precision Oncology Foundation (ICPO). The hospital now joins only two other centres in South Africa to achieve this prestigious recognition.

The certification followed a rigorous evaluation process by the ICPO Foundation, which assessed the department’s clinical standards, infrastructure, expertise, and commitment to advancing theranostics. The application and verification process was done by Dr Tebatso Tebeila, a senior resident at the department who has just passed her final exams. She was supported by Dr Gerrit Engelbrecht, Head of the UFS Department of Nuclear Medicine, in the process which included interviews with the ICPO accreditation and projects director Dr Marwa Hakkam. Dr Tebeila had also completed the ICPO short course in Radiomolecular Precision Oncology through the ICPO Academy of Theranostics.

The UAH Nuclear Medicine Department began theranostics activities about five years ago, particularly in neuroendocrine and prostate malignancies. Prof Osayande Evbuomwan, Senior Lecturer and medical specialist in nuclear medicine in the UFS Department of Nuclear Medicine, received training for this during his residency period and had completed a rigorous international training workshop organised by the International Atomic Energy Agency on theranostics, particularly in prostate cancer, neuroendocrine neoplasms and well differentiated thyroid cancer. Prof Evbuomwan passed all these training and skills down to the department. The certification was further strengthened by the installation of department’s new state-of-the-art digital PET/CT camera, placing it on par with similar academic departments in the country. The recognition was officially conferred during the ICPO Reception at the European Association of Nuclear Medicine Congress in Barcelona earlier this month.  

 

A milestone achievement

“Being granted this certification signifies international recognition of our hospital’s commitment to the highest clinical, academic, and ethical standards in theranostics. It confirms that our institution meets the global benchmarks for delivering precision oncology care that integrates diagnostics and therapy for personalised cancer management.

“For our department and the University of the Free State, this is a milestone achievement that highlights our leadership in nuclear medicine and molecular imaging. It strengthens our research and training capacity and also attracts residents who want to be trained in nuclear medicine. It also enhances collaboration with international partners and aligns with our mission to advance precision medicine in South Africa and beyond,” says Prof Evbuomwan.

Theranostics, he explains, is an aspect of nuclear medicine that involves the use of a tracer bound to a radioisotope that can specifically locate and image cancer cells with high precision, characterise them and determine how much radiation will get to them. Using the same tracer, but a different radioisotope for therapy, these cancer cells are targeted with high precision and destroyed. It could be so precise that it targets only the cancer, sparing most of the normal tissue and thus resulting in less serious side effects. It is an aspect of nuclear medicine that is bound to revolutionise cancer care.

Dr Gerrit Engelbrecht says as a department, they are honoured and deeply proud of this achievement as it reflects months of dedication, innovation, and teamwork. “It validates our commitment to excellence in improving patient care and academic advancement, and we are motivated to build on this success. We are also grateful to Dr Tebeila for her initiative, hard work, dedication and networking skills.

“We would like to thank the ICPO Foundation for this recognition and for its continued efforts to support theranostics in developing regions. We also acknowledge the hard work of our staff, and partners who made this possible. This milestone inspires us to continue driving innovation and equitable access to precision oncology in Bloemfontein, the Free State province and South Africa at large.”

 

Forefront of precision oncology 

According to Prof Evbuomwan, patients will also benefit from this certification as it translates to improved access to world-class, and evidence-based theranostic management. It means earlier diagnosis, more accurate therapy selection, and ultimately, better treatment outcomes and quality of life for those with some of these cancers. They strongly believe the patients in the Free State also deserve access to this management, as the world is now moving slowly into the era of personalised and precision medicine. The Universitas Academic Hospital is now among three centres in South Africa (Numeri in SBAH Pretoria and Umhlanga Molecular Imaging and Therapy Centre in Durban) to achieve this prestigious recognition, joining an international network of 46 centres, mostly located in low- and middle-income countries. This positions the UFS at the forefront of precision oncology on the African continent.

Prof Evbuomwan says they hope to use this new status to expand patient access to theranostic treatments, foster multidisciplinary collaborations within the Universitas academic circuit, and participate in global research initiatives through the ICPO Academy for Theranostics. Certifications like this, he continues, would also help to attract more staff and junior resident doctors to the facility. It will also help them train the next generation of nuclear medicine specialists and strengthen South Africa’s role in precision oncology. The ICPO will also offer direct assistance to the facility to achieve these objectives.

On her trip to the EANM Congress in Barcelona to receive the certificate and to attend the international congress, Dr Tebeila said it is always such an honour to attend international conferences and this year’s EANM was particularly invigorating with the latest scientific presentations in various theranostic applications by peers and well-known experts in the global nuclear medicine sphere. 

“The highlight was, of course, attending the annual Oncidium Foundation Ambassadors meeting and being part of the ICPO certification ceremony along with my counterparts from 23 other centres spanning Asia, Arab regions and Africa. 

“My wish is to see the UAH nuclear medicine department grow in leaps and bounds, epically in patient reach, clinical research with academic expansion and overall excellence in service delivery. This ICPO theranostics centre of excellence certification is only the beginning of what is to come.”

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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