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10 June 2020 | Story Leonie Bolleurs | Photo Supplied
Prof Zakkie Pretorius, left, plays a significant role in providing pathology support to the plant breeding industry.Prof Liezel Herselman contributes to plant breeding in Southern Africa by training and mentoring the plant breeders of the future.

The Southern African Plant Breeders’ Association (SAPBA) recently bestowed prestigious awards upon Prof Zakkie Pretorius, Research Fellow in the Department of Plant Sciences at the University of the Free State (UFS), and Prof Liezel Herselman, Associate Professor in the same department. This institution strives to maintain high ethical standards and norms, contributing to stable, sustainable agriculture.

During the 13th Southern African Plant Breeders’ Association symposium, Prof Herselman was presented with a Fellow Award and Prof Pretorius with Honorary Membership. They received the awards for their services to and promotion of the SAPBA objectives, together with their exceptional contributions to plant breeding. 

Provide food for the nation
Over the years, Prof Pretorius, who has extensive expertise in diseases of field crops – more specifically the rust diseases of small grain cereal crops – has played a significant role in providing pathology support to the plant breeding industry. He has also conducted ground-breaking pathology research on rust diseases in field crops. In 2019, he co-authored an article that appeared in Nature, the world’s leading multidisciplinary science journal. He is also shortlisted as a 2020 finalist in the Lifetime Award and Special Theme Award (Plant Health) of the National Science and Technology Forum. Furthermore, he regularly attended and participated in biennial conferences and supervised plant breeding students working on plant disease projects. 

Prof Herselman contributes to plant breeding in Southern Africa by training and mentoring the plant breeders of the future. “As a lecturer of fourth-year and honours Plant Breeding students, as well as supervisor and promoter of master’s and doctoral students, I am in the fortunate position to teach and mentor my students in one of the newest fields of plant breeding, namely marker-assisted plant breeding. All future plant breeders need this knowledge to make a success of their breeding programmes. Our students are the future plant breeders who will provide food to the nation,” she says. 

"As a plant pathologist, I am privileged to have been able to contribute to the quest for disease resistance in crop improvement and to have been recognised for it.” – Prof Zakkie Pretorius
The highest honour
Prof Pretorius view recognition by the industry – in this case, the plant breeding fraternity – as the highest honour for someone working in agricultural science. “As a plant pathologist, I am privileged to have been able to contribute to the quest for disease resistance in crop improvement and to have been recognised for it. I am also extremely grateful to colleagues and co-workers who have contributed over many years to the establishment of a productive and influential research group at the UFS,” he says.

Prof Herselman shares this sentiment. She says: “It means so much to me to know that I have made a difference and an impact on my students’ lives. It is a privilege to have the opportunity to work with under- and postgraduate students and to see them grow.”

She continues: “We strive to send out well-rounded students who can make a difference in the workplace and the community. This award means that I have succeeded in this goal, even though I do my work because I am passionate about it and not to receive recognition.”

Fight against fungal disease continues
Prof Pretorius continues to be involved in studies on host plant resistance and pathogenic variability. 

As a molecular plant breeder, Prof Herselman is pushing on with research focusing on the development of wheat lines with improved disease resistance. The work that she is doing makes a difference on both national and international level. “As part of my current research programme, we have made rust- and Fusarium head blight-resistant wheat lines available to South African breeding companies for use in their breeding programmes. The lines developed at the UFS will in a small way contribute towards the fight against fungal diseases in South Africa, thus securing the yield and livelihoods of farmers and consumers,” she says.

Her master’s and doctoral students who have completed their studies, also take the knowledge they gained at the UFS back to their countries and workplaces where they ultimately add value, especially contributing towards the fight against hunger. 

"“We strive to send out well-rounded students who can make a difference in the workplace and the community. This award means that I have succeeded in this goal, even though I do my work because I am passionate about it and not to receive recognition.” – Prof Liezel Herselman

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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