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29 October 2020 | Story Thokozane Ngcongwane | Photo Supplied
Thokozane Ngcongwane recommends that students and staff should actively seek help for their mental-health challenges.

My name is Thokozane Ngcongwane. I coordinate the UFSS1504 module in the Centre for Teaching and Learning (CTL). The journey of struggles and triumphs against mental illness has often peppered my life more than I thought. Having grown up in rural Free State, it was hard for my parents, as well as those around me, to believe that things such as mental illness exist – let alone their own son! 

I grew up with attention-deficit / hyperactivity disorder (ADHD) and was admitted numerous times as the illness was misdiagnosed and untreated. This laid the foundation for a childhood filled with amazing feats of energetic activity, but also had the downside of being misunderstood, or ill-treated due to this illness. Before I knew about this illness, I believed that because of my height (I have been given the names ‘Napoleon’ and ‘Goliath’ by various people, throughout) and stature. I was a prime target for bullying. 

Fast forward to university, and with the world as my oyster, I believed I would do well, graduate, and become the scientist I have always dreamed of becoming. Nothing could prepare me for the roller-coaster ride that, even to this day, has taught me highly valuable life lessons that I would never have received anywhere else. I started a degree in Chemistry (Extended) and was doing well in the first year. I was even fortunate enough to be selected for the F1 Leadership for Change exchange programme that took me to the USA. That was an incredible experience. Fast forward to my third year, and things took a turn for the worse. 

By 2013, I started getting panic and anxiety attacks, the origin of which was quite unknown to me at the time. I thought that I was starting to go insane and this caused a huge drop in my academics, as well as distorting my overall view on life. I started refusing to see friends and family and even shunned myself from engaging in academics. This was the start of my battles and little prepared me for the fight ahead. I took a trip outside of my surroundings and became aware of how the people I avoided cared for me, and the result was that I overcame anxiety for that period. Family, friends, and lecturers were supportive and encouraged me to do my best amid this unknown period in my life. My academics improved and I became social again. 

When I thought the worst was behind me, I was diagnosed with generalised anxiety disorder (GAD). I contacted Student Counselling and Development and received professional assistance. I started feeling better again and was on my way to graduating, albeit the journey was fraught with anxious moments. My graduation was delayed due to a credit shortfall, and this threw me in the deep end once again. This time, I dealt with it better by engaging myself in my passions – sports and the outdoors. I graduated in May 2016 and secured a temporary job as a Science teacher.

I returned home to the Qwaqwa Campus, where I became an intern in CTL. My troubles reached a boiling point in 2019, and I contacted Careways on recommendation of my head of department. It is now 2020, the year of global anxieties. I have learnt that institutions such as the South African Depression and Anxiety Group (SADAG) are available to help. Higher Health is also available to deal with issues around stigmatisation. In short, seek help and never abandon your support structures. Your mental health matters.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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