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18 August 2021 | Story André Damons | Photo André Damons
Dr Osayande Evbuomwan is a Senior Lecturer and medical specialist in nuclear medicine in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS).

The University of the Free State (UFS) Department of Nuclear Medicine has, for the first time, started using Lutetium 177 PSMA (Lu-177 PSMA) therapy for the treatment of metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer.

The UFS and the Free State province are now joining other South African universities, such as the University of Pretoria, the University of the Witwatersrand, and other provinces in using this method to treat MCRPC patients. 

Dr Osayande Evbuomwan, a Senior Lecturer and medical specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, says they have started treating their first MCRP patient (first cycle) with peptide receptor radionuclide therapy (PRRT) on 15 July. It is the first time that Lutetium 177 PSMA – a type of PRRT used for treating patients with MCRPC – has been used in the Free State. This method is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Expertise and funds are now available for this treatment

Dr Evbuomwan was trained and exposed to this therapy at the University of the Witwatersrand during his registrar training in nuclear medicine. When he joined the UFS in 2019, he – with the always available help of the Head of Department, Dr Gerrit Engelbrecht – pushed for the therapy to be used in the department. 

“We in the Department of Nuclear Medicine are happy that expertise is now available and that some funds have been released for this treatment to commence. The index patient is very sick with MCRPC and was too sick to qualify for first-line chemotherapy. Each patient will need about four-six cycles for complete treatment. The patient is being treated in the Department of Nuclear Medicine at the Universitas Academic Hospital and Annex.” 

“We are hoping that he will be able to complete at least four cycles and respond well to the treatment. We believe that the ability to administer this treatment now is good news for the Free State, as the people of the Free State also deserve to be exposed to this level of treatment. We are hoping that the government will continue to provide more funds for more of these patients to be treated in our facility,” says Dr Evbuomwan.

It was budgeted to treat five patients (20 cycles), with each cycle (just the Lu-177 PSMA) costing more than R50 000. 

A googled image from the internet of a case before, during, and after completing the full course of therapy. The first image is before
treatment and the last image is after completing treatment, while the images in between are during treatment.
(Source: Google) 

Prostate cancer one of the leading causes of morbidity and mortality

Dr Evbuomwan says prostate cancer is one of the leading causes of morbidity and mortality in the world, including South Africa. When it progresses to the advanced stage of MCRPC, the prognosis becomes bad. 

Dr Evbuomwan explains that there are various conventional systemic therapies, including first- and second-line chemotherapy that could be used to treat patients at this bad stage. However, not all patients are fit for chemotherapy. The few who are fit, according to Dr Evbuomwan, usually end up failing the first-line chemotherapy, which has a lot of undesirable side effects and require long-stay hospital admissions. 

Only a few centres are able to offer second-line chemotherapy. So many of these patients end up suffering from prolonged bone pains before eventually dying from the disease.

PRRT is a targeted nuclear medicine therapy that offers the opportunity to deliver very high levels of radiation specifically to cancer cells, because these cancer cells express specific receptors to which certain peptides can bind. This specificity to cancer cells offers the advantage of providing lower doses of radiation and damage to normal organs and tissues, a characteristic that conventional therapies do not offer, explains Dr Evbuomwan.  

According to him, Lutetium 177 PSMA (Lu-177 PSMA) is a type of PRRT used for treating patients with MCRPC, who are not eligible for chemotherapy or have failed first-line chemotherapy. Numerous research studies around the world have proven that this treatment improves quality of life, slows down disease progression, and improves overall survival, with little or very tolerable side effects in most patients. 

The University of Pretoria is one of the pioneers of this treatment in the world, having done a lot of research with it since 2017. Other provinces such as the Western Cape and KwaZulu-Natal have also recently become involved with the therapy. This therapy is expensive and requires a lot of expertise. It also involves the input of a multidisciplinary team (MDT), which must at least include a nuclear medicine physician, a radiation oncologist, and a urologist. The Departments of Urology and Radiation Oncology at the UFS were also instrumental in the initiation of the therapy and form part of the MDT team at the UFS in the management of these patients.

Treatment puts department, university, and hospital on the map

Dr Evbuomwan says the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. “It also creates an avenue for us to gather data for research purposes and for publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients no longer need to travel to other provinces to get the treatment.”

There are plans to expand the treatment to more patients – and hospital management, who were present at the first treatment, are excited and looking forward to the outcome of this current treatment.

Watch video below:

News Archive

Boyden Observatory turns 120
2009-05-13

 

At the celebration of the 120th year of existence of the UFS's Boyden Observatory are, from the left: Prof. Herman van Schalkwyk, Dean: Faculty of Natural and Agricultural Sciences at the UFS, Prof. Driekie Hay, Vice-Rector: Academic Planning at the UFS, Mr Ian Heyns from AngloGold Ashanti and his wife, Cheryl, and Prof. François Retief, former rector of the UFS and patron of the Friends of Boyden.
Photo: Hannes Pieterse

The Boyden Observatory, one of the oldest observatories in the Southern Hemisphere and a prominent beacon in Bloemfontein, recently celebrated its 120th year of existence.

This milestone was celebrated by staff, students, other dignitaries of the University of the Free State (UFS) and special guests at the observatory last week.

“The observatory provides the Free State with a unique scientific, educational and tourist facility. No other city in South Africa, and few in the world, has a public observatory with telescopes the size and quality of those at Boyden,” said Prof. Herman van Schalkwyk, Dean of the Faculty of Natural and Agricultural Sciences at the UFS.

The observatory, boasting the third-largest optical telescope in South Africa, has a long and illustrious history. It was established on a temporary site on Mount Harvard near the small town of Chosica, Peru in 1889. Later it was moved to Arequipa in Peru where important astronomical observations were made from 1891 to 1926. “However, due to unstable weather patterns and observing conditions, it was decided to move the Boyden Station to another site somewhere else in the Southern Hemisphere, maybe South Africa,” said Prof. Van Schalkwyk.

South Africa's excellent climatic conditions were fairly well known and in 1927 the instruments were shipped and the Boyden Station was set up next to Maselspoort near Bloemfontein. Observations began in September 1927 and in 1933 the new site was officially completed, including the 60 inch (1.5 m) telescope, which was then the largest optical telescope in the Southern Hemisphere. This telescope was recently refurbished to a modern research instrument.

The observatory has various other telescopes and one of them, the 13" refractor telescope, which was sent to Arequipa in 1891 and later to Bloemfontein, is still in an excellent condition. Another important telescope is the Watcher Robotic Telescope of the University College Dublin, which conducts many successful observations of gamma ray bursts.

“In the first few decades of the twentieth century, the Boyden Observatory contributed considerably to our understanding of the secrets of the universe at large. The period luminosity relationship of the Cepheid variable stars was, for example, discovered from observations obtained at Boyden. This relationship is one of the cornerstones of modern astrophysics. It is currently used to make estimates of the size and age of the universe from observations of the Hubble Space Telescope,” said Prof. Van Schalkwyk.

“The Boyden Observatory contributed to the university’s astrophysics research group being able to produce the first M.Sc. degrees associated with the National Space Science Programme (NASSAP) in the country and the Boyden Science Centre plays an important role in science and technology awareness of learners, teachers and the general public,” said Prof. Van Schalkwyk.

The Boyden Science Centre has also formed strong relationships with various institutions, including the South African Agency for the Advancement of Science and Technology (SAASTA) and the Department of Science and Technology. The centre has already conducted many different projects for the Department of Science and Technology, including National Science Week projects, as well as National Astronomy Month projects. It also serves as one of the hosts of SAASTA’s annual Astronomy Quiz.

Media Release:
Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
13 May 2009
 

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