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03 December 2021 | Story Lunga Luthuli | Photo Supplied
Geraldine Lengau, Senior Officer in the UFS Gender Equality and Anti-Discrimination Office within the Unit for Institutional Change and Social Justice, calls on men to take the lead in ending gender-based violence.

Gender-based violence is a phenomenon deeply rooted in gender inequality and the scourge continues to be one of the most notable human rights violations, with many communities – especially women and children – suffering the most from the atrocious acts. 

South Africa remains the country with the highest number of violent acts, especially against women, and Statistics South Africa reports that one in five partnered women has experienced physical violence. 

Gender-based violence can take many forms, including 

• sexual harassment; 
• rape and/or sexual violence;
• stalking (deliberately and repeatedly following, watching, and/or harassing another person);
• physical, emotional, and economic abuse; and
• child abuse.

Geraldine Lengau, Senior Officer in the Gender Equality and Anti-Discrimination Office within the Unit for Institutional Change and Social Justice, says: “Individuals must be vigilant of toxic environments where emotional and physical abuse are rampant.”

 “Even in the workplace, individuals can experience gender-based violence and it can play itself out in the form of power dynamics, prejudice, and discrimination.”

To help end gender-based violence at work, Lengau says, “Institutions have a duty to implement policies and procedures to increase awareness and sensitisation about this pandemic.”

Societal norms often contribute to victims deciding not to report these criminal acts for fear of being judged, with many women still being considered guilty of attracting violence against themselves through their behaviour.

“It is important for communities to provide support to victims and for organisations to have a zero gender-based violence tolerance policy. Victims must report any act, and in extreme cases, they must not be shy to get a protection order,” Lengau says. 

With the 16 Days of Activism for No Violence against Women and Children Campaign in full swing, Lengau says, “It is a great international initiative to tackle and raise awareness around issues of gender-based violence; however, it is not enough. It should go beyond the 16 days.”

 “To rid society of gender-based violence, our communities – men and women – should work together to root it out. Men should take the lead in tackling issues and bringing about solutions. Women should never get tired of speaking out; there is help for them.”

“Gender-based violence is a societal ill and women need to know that they should not bear the shame,” she says.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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