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25 April 2022 | Story Elsabé Brits
Andre Roodt and Alice Brink
Prof Andreas Roodt and Prof Alice Brink are two of the inventors of the ‘Multinuclear complexes and their preparation patent.

According to the World Health Organisation (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six. The most common cancers are breast, lung, colon, rectum, and prostate cancers. There is a constant need to provide methods to diagnose and treat cancer-related tumours.  Current research strategies focus on eliminating cancer cells with the minimum damage to surrounding healthy cells.

A limitation of current technologies is that they are mostly based on the separate identification of cancer (diagnostic), followed by treatment (therapy) using chemotherapy and/or radiotherapy. To fit both needs at the same time and with similar or identical compounds, the principle of theranostic medicine was identified. This concept employs both diagnosing (by imaging) cancer and delivering therapy (treatment) simultaneously, which has been receiving increased attention internationally.

Collaborating with the University of Zurich
A University of the Free State (UFS) team, together with a team from the University of Zürich, conducted exciting research in this area and filed a patent titled ‘Multinuclear complexes and their preparation’. The patent was granted in South Africa and by the European Patent Office. It is being validated in selected European countries. The patent is pending in the USA, Japan, Hong Kong, and India. The inventors from the UFS are Prof Andreas Roodt, Prof Alice Brink, Dr Pennie Mokolokolo, and Dr Vincent Dumisani Kama. The approach that their technology takes is to enable the synthesis of a multinuclear compound/s, which may contain different pre-selected radioisotopes, to allow both imaging and therapy to the cancer site(s) with one and the same metal-organic complex.

So far, high-yield production of compounds has been successfully innovated, which contain both an imaging (in particular the widely utilised imaging isotope Technetium-99m) and therapeutic (typically the therapeutic isotope Rhenium-186) radioactive isotope(s), optionally carrying an additional cytotoxic agent. (Chemotherapy uses anti-cancer [cytotoxic] drugs to destroy cancer cells.)

Nuclear medicine technologies
In the next phase of the research, a lead compound portfolio of four to five model pharmaceuticals containing these metal nuclides with appropriate directing groups to target cancer sites will be designed and constructed. A number of these entities are known and can be introduced through different techniques. These will then undergo full characterisation and efficacy evaluation in biological models (in vitro), followed by extensive animal and human trials.

The technology will be delivered as a product or service in the way that current nuclear medicine technologies are delivered.

The fact that this product(s) contains both imaging and therapeutic radionuclides or cytotoxic modalities, enables detailed tracking of the pharmaceutical and monitoring of the tumours' response to the therapy. Not directly related to the patent, but an asset to it, is the fact that the incorporation of rhenium with a high atomic number (Z = 75) opens the additional opportunity to utilise the multinuclear compounds also as radiosensitisers. Synergistic effects, enhancing the therapeutic efficacy, can thus be expected in combination with radiotherapy.

The UFS would like to partner with a pharmaceutical company working in the field of nuclear medicine to commercialise this technology. Interested parties can contact Ravini Moodley at MoodleyR5@ufs.ac.za

News Archive

The King’s Singers: British double Grammy winners hosted by OSM
2017-01-24

 Description: The Kings Singers Tags: The Kings Singers

The King’s Singers regularly tour in Europe, North and
South America, Asia and Australasia. The group will be
performing in Bloemfontein on 14 February 2017.
Photo: Andy Staples

The King’s Singers, the acclaimed British a cappella vocal ensemble, are coming to Bloemfontein, hosted by the Odeion School of Music at the University of the Free State, for an unmissable performance.

Concertgoers from Bloemfontein and surrounding areas have the opportunity to experience this extraordinary vocal ensemble at the Dutch Reformed Church Universitas at a concert sponsored by the Arts Trust.

Named after King’s College in Cambridge, the group was formed in 1965, and for the past 48 years, their work, synonymous with the very best in vocal ensemble performance, appeals to a vast international audience.

The ensemble has performed for hundreds of thousands of people each season, and regularly tours Europe, North and South America, Asia and Australasia. Instantly recognisable for their immaculate intonation, vocal blend, diction and incisive timing, the King’s Singers are consummate entertainers.

The group’s repertoire has evolved to become one of the most diverse and compelling imaginable. They have commissioned more than 200 works, including landmark pieces from leading contemporary composers including Luciano Berio, György Ligeti, Sir James MacMillan, Krzysztof Penderecki, Toru Takemitsu, Sir John Tavener, Gabriela Lena Frank and Eric Whitacre. They have also commissioned arrangements of everything from jazz standards to pop chart hits, explored medieval motets and Renaissance madrigals, and encouraged young composers to write new scores.

In addition to performing to capacity audiences and creating highly regarded and much-loved recordings, the King’s Singers share their artistry at numerous workshops and masterclasses around the world.  

Double Grammy award-winning artists, the group were honoured in 2009 for their Signum Classics release, Simple Gifts, and again in 2012 for their contribution to Eric Whitacre’s Light and Gold album. Recently voted into Gramophone Hall of Fame, rave reviews and repeated sell-out concerts confirm that the King’s Singers are one of the world’s finest vocal ensembles.

Watch videos of the The King’s Singers:
The King's Singers - Overture The Barber Of Seville
2016 Pioneer Day Concert with The King's Singers - Primary Medley
A Christmas Songbook by The King's Singers

Date: 14 February 2017
Time: 19:30
Place: Dutch Reformed Church Universitas, Bloemfontein
Cost: R295 per person | R268 per person for group bookings of 10+

Tickets for the concert are available at Computicket outlets (Checkers, Shoprite shops), at the door, or online.

For inquiries or more information, contact Ninette Pretorius at +27 51 401 2504.

 

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