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25 April 2022 | Story Elsabé Brits
Andre Roodt and Alice Brink
Prof Andreas Roodt and Prof Alice Brink are two of the inventors of the ‘Multinuclear complexes and their preparation patent.

According to the World Health Organisation (WHO), cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six. The most common cancers are breast, lung, colon, rectum, and prostate cancers. There is a constant need to provide methods to diagnose and treat cancer-related tumours.  Current research strategies focus on eliminating cancer cells with the minimum damage to surrounding healthy cells.

A limitation of current technologies is that they are mostly based on the separate identification of cancer (diagnostic), followed by treatment (therapy) using chemotherapy and/or radiotherapy. To fit both needs at the same time and with similar or identical compounds, the principle of theranostic medicine was identified. This concept employs both diagnosing (by imaging) cancer and delivering therapy (treatment) simultaneously, which has been receiving increased attention internationally.

Collaborating with the University of Zurich
A University of the Free State (UFS) team, together with a team from the University of Zürich, conducted exciting research in this area and filed a patent titled ‘Multinuclear complexes and their preparation’. The patent was granted in South Africa and by the European Patent Office. It is being validated in selected European countries. The patent is pending in the USA, Japan, Hong Kong, and India. The inventors from the UFS are Prof Andreas Roodt, Prof Alice Brink, Dr Pennie Mokolokolo, and Dr Vincent Dumisani Kama. The approach that their technology takes is to enable the synthesis of a multinuclear compound/s, which may contain different pre-selected radioisotopes, to allow both imaging and therapy to the cancer site(s) with one and the same metal-organic complex.

So far, high-yield production of compounds has been successfully innovated, which contain both an imaging (in particular the widely utilised imaging isotope Technetium-99m) and therapeutic (typically the therapeutic isotope Rhenium-186) radioactive isotope(s), optionally carrying an additional cytotoxic agent. (Chemotherapy uses anti-cancer [cytotoxic] drugs to destroy cancer cells.)

Nuclear medicine technologies
In the next phase of the research, a lead compound portfolio of four to five model pharmaceuticals containing these metal nuclides with appropriate directing groups to target cancer sites will be designed and constructed. A number of these entities are known and can be introduced through different techniques. These will then undergo full characterisation and efficacy evaluation in biological models (in vitro), followed by extensive animal and human trials.

The technology will be delivered as a product or service in the way that current nuclear medicine technologies are delivered.

The fact that this product(s) contains both imaging and therapeutic radionuclides or cytotoxic modalities, enables detailed tracking of the pharmaceutical and monitoring of the tumours' response to the therapy. Not directly related to the patent, but an asset to it, is the fact that the incorporation of rhenium with a high atomic number (Z = 75) opens the additional opportunity to utilise the multinuclear compounds also as radiosensitisers. Synergistic effects, enhancing the therapeutic efficacy, can thus be expected in combination with radiotherapy.

The UFS would like to partner with a pharmaceutical company working in the field of nuclear medicine to commercialise this technology. Interested parties can contact Ravini Moodley at MoodleyR5@ufs.ac.za

News Archive

Top achievers arrive at UFS
2017-01-26

Description: Tshepo Thajane Tags: Tshepo Thajane

Tshepo Thajane, winner of the Kovsies
Star of Stars competition.
Photo: Eugene Seegers

Although first-year registration officially started on 23 January 2017 at the University of the Free State (UFS), the Marketing department invited some of the top-achieving matrics in the country to an event on Friday 20 January to assist them with early registration. These high-flying pupils have AP scores of 40 and above, and worked hard to get to where they are today, with driving ambition for their future.

The #StarOfStars
Tshepo ”Doctor” Thajane is the winner of the newly-established Kovsies Star of Stars competition, and as such received a full bursary from the UFS, among other sponsorships. He has enrolled in Actuarial Sciences and will be housed at the Karee residence. When asked what drew him to our university, he responds: “I just loved the university before I entered it, and I chose the UFS because of the respect I was shown.”

Friendly reception
Lendl Ontong will be pursuing his LLB in the Faculty of Law, and has obtained a place in the brotherhood of the Karee residence. The Ontong family hails from Worcester in the Western Cape. Lendl’s father, Mr Lionel Ontong, had this to say of his experience: “The staff at the UFS, especially at the admissions office, is the friendliest group of people I’ve ever come across, and helpful as well. My wife was sceptical when I told her about the friendly treatment I experienced when I phoned the university, but when she witnessed it today, she could see it first-hand. The friendliness is contagious, and even though I’m tired after the long journey, their attitude has rubbed off on me. And my wife now has the assurance that her child is going to be happy here. The atmosphere is one of homeliness. It’s fantastic! Even the netball coach introduced herself to my son and invited him to pop in for a cup of tea, and she won’t even be involved with his university journey. It meant a lot to us as parents.”

Description: Jani Gerber  Tags: Jani Gerber

Jani Gerber and her dad Jaco Gerber.
Photo: Eugene Seegers

Runs in the family

Jani Gerber is a second-generation Kovsie who hails from Port Elizabeth. She won the cultural division in the Matriculant of the Year competition in 2016 and was invited to join the UFS. According to her, she “didn’t even consider another university”.

Her dad, Mr Jaco Gerber, says: “The whole process of application and registration was very efficient and professional. Jani’s older sister, Anri, completed her MBChB at UFS last year and is currently working at the Pelonomi Regional Hospital. Jani has already been adopted by new friends in her residence. She says, “Some charming students welcomed us at the residence, and even helped out when we were unpacking.” Jani has aspirations to sing in the annual Stagedoor and Serenade Singoff competitions.

We welcome all our first-years and look forward to supporting them throughout their university journey!

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