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03 January 2022 | Story André Damons | Photo Supplied
Seven supported academics from the Afromontane Research Unit (ARU) on the Qwaqwa Campus saw an increase in their H-indices (Google Scholar) during 2020.

Over the past few years, the university has implemented special interventions to increase the diversity of UFS researchers, including targeted appointments and focused research capacity development and support. Strategic interventions relating to National Research Foundation (NRF) rating resulted in the UFS having a well-established cohort of rated researchers.  

According to the recent internal research report, the UFS has 144 researchers in the A, B and C categories (established according to NRF criteria), and 57 researchers under the age of 40 who are considered emerging researchers in the P and Y categories. This brings the total to 201 rated researchers in 2021, compared to 188 in 2020, and 164 in 2019. The university also has 57 Y-rated researchers.  

Furthermore, the university submitted 51 applications to the NRF under the 2020 rating call, including 21 first-time applications (of which four were unsuccessful) and 26 who were invited to reapply to keep their ratings active (of which all were successful).

Prof Corli Witthuhn, Vice-Rector: Research and Internationalisation, says the UFS has been able to appoint outstanding young researchers over the past eight years.  “Not only did these exceptional individuals contribute to our scholarship and research productivity, but they also increased our diversity. The increase in the diversity of our NRF-rated academics is an aspect of the research portfolio that I am most proud of,” says Prof Witthuhn.  

Highlighted trends regarding NRF-rated researchers

• There has been a constant growth in the number of rated researchers, from 127 in 2016 to 202 in 2021.
• The majority of NRF-rated researchers (186 in 2021) are from the Bloemfontein Campus. The number of rated researchers from the Qwaqwa Campus increased from 4 in 2016 to 13 in 2021. The South Campus increased its number of rated researchers by two in 2021, with a current total of three rated researchers.
• The Faculty of Natural and Agricultural Sciences has the highest percentage of rated researchers (45%) in 2021, followed by the Faculty of the Humanities (29%).
• The percentage of rated white researchers declined from 92% in 2016 to 78% in 2021, and the rated black researchers increased from 6% in 2016 to 17% in 2021.
• The percentage of rated female researchers increased from 27% in 2016 to 34% in 2021.
• Rated researchers in the C2 and C3 rating categories declined slightly, from 52% in 2019 to 47% in 2021. There is still positive growth in the number of young (Y1/Y2) rated researchers – from 14% in 2016 to 27% in 2021.

Ratings and promotions  

The university hosts a total of six South African Research Chairs (SARChI) funded by the NRF / Department of Science and Innovation (DSI), of which four are held by women. Three chairs are appointed in the Faculty of Natural and Agricultural Sciences and the Faculty of Education, while the faculties of Economic and Management Sciences and Health Sciences appointed one chair each. Two research chairs have been renewed for 2021-2025.  

Seven supported academics from the Afromontane Research Unit (ARU) on the Qwaqwa Campus saw an increase in their H-indices (Google Scholar) during 2020, while one new Y1 NRF rating was awarded and another was increased to C2 level. Two ARU-supported academics achieved professorial status in the same year.

Twenty-five young academics on the cusp of NRF rating and promotion to the rank of Associate Professor are participating in the Future Professoriate Mentoring Programme, while the 25 participants of the ESAP group have completed their doctorates over the past three years and are working towards obtaining a Y-rating. As a result of the outstanding progress of the first cohort of the mentoring programme during 2020, a second cohort of ESAP scholars was selected in March 2021. More than 80% of the 75 group members are younger than 40 years.

Drs Frans Kruger and Lodewyk Sutton also received NRF Y-ratings in November 2020. The ESAP programme currently has three recipients of the FirstRand NRF Black African Advancement Fellowship Programme: Dr Eugene Baron (Practical Theology), Dr Mirriam Moleko (School of Mathematics and Science Education), and Dr Neo Pule (Psychology). Dr Lizemari Hugo from the School of Nursing also received a FAIMER (Foundation for Advancement of International Medical Education and Research) fellowship. Dr Mikateko Höppener (Centre for Development Support) has been selected to participate in the national DHET Future Professoriate Programme.

Publication output units show significant increase 

The publication output units (books, conference proceedings, and journal articles) by UFS researchers, as measured and reported to the Department of Higher Education and Training (DHET), show consistent growth from 2016 to 2020. The output units increased significantly in 2019 and 2020 after a slight decrease in 2017.

There has also been a notable increase in books/chapters since 2018. Journal articles also showed constant growth from 2017 onwards, especially from 2019 to 2020, with a 20% growth in journal outputs visible; however, conference proceedings declined last year.  

Main contributors 

The faculties of Natural and Agricultural Sciences, the Humanities, and Theology and Religion remain the main contributors to the university’s publication output. Four faculties (Economic and Management Sciences, Education, Health Sciences, and Theology and Religion) increased their share of units in 2020 compared to the 2016-2019 period.

The journal output units generated from scholarly articles published in internationally indexed journals remained more than 80% (82% in 2017, 85% in 2018, 81% in 2019, and 85% in 2020). Only 15% of journal articles were published in South African indexed (DHET) journals (compared to 24% in 2016). Since 2016, there has been a clear shift towards publications in internationally indexed journals.

The following nine in-house journals are being administered by the UFS:

Acta Academica (editor: Henning Melber), Acta Structilia (editor: K Kajimo-Shakantu), Acta Theologica (editor: Jan-Albert van den Berg), Communitas (editor: Willemien Marais), Journal for Juridical Science (editor: Bradley Smith), Journal for Translation Studies in Africa (editor: Kobus Marais), Perspectives in Education (editor: Jan Nieuwenhuis), Southern Journal for Contemporary History (editor: Neil Roos), and Town and Regional Planning (editor: Maléne Campbell).

All are DHET-accredited, except for the Journal for Translation Studies in Africa, a new KovsieJournals title.

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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