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15 June 2023 | Story Lunga Luthuli | Photo Lunga Luthuli
Martie and Charity
Martie Miranda, Deputy Director of CUADS, and Charity Morrison, CUADS Disability Support Manager, have been nominated to lead a Universities South Africa Transformation Managers Forum (USAf TMF) task team to review universal access and disabilities support in the public higher education sector.

Two staff members from the UFS Centre for Universal Access and Disability Support (CUADS) have been nominated to lead a Universities South Africa Transformation Managers Forum (USAf TMF) task team to review universal access and disabilities support in the public higher education sector.

Martie Miranda, Deputy Director of CUADS, and Charity Morrison, CUADS Disability Support Manager, were nominated after a TMF Transformation Strategy Group meeting held in March 2023, at which an assessment of the implementation of the Department of Higher Education and Training’s Strategic Policy Framework on Disability for the Post-school Education and Training System in the public higher education sector was adopted as a group priority. The task team will be run in collaboration with the Higher and Further Education Disability Services Association (HEDSA).

Their nomination to lead the task team is an expression of “the UFS’s commitment to instilling values of care and social justice where staff and students have a sense of belonging”, said Miranda.

Miranda, who currently serves as HEDSA Chairperson, says, “The focus for the task team is to unpack the Strategic Policy Framework’s expectations, and identify the themes and deliverables expected of the higher education institutions (HEIs).”

Supported by Morrison, she will lead a team of volunteers from the TMF and co-opted stakeholders in HEIs in developing a survey questionnaire to examine the status of implementation of the Strategic Policy Framework. The team will submit a report and recommendations to the TMF in November 2023. 

“I am looking forward to tapping into everyone’s expertise, and for the University of the Free State to participate in the survey, which will assist in reflecting on where the institution is on inclusivity and disability transformation,” Miranda says.

Leading transformation and an inclusive agenda

Depending on the findings and recommendations, the task team might be required to monitor and evaluate progress going forward. 

“Serving on the task team gives us the opportunity to see what is happening on the ground, and to make recommendations that will enhance the inclusion of people with disabilities,” Morrison says. “The recommendations will assist with changing the culture of institutions and create a better student experience and well-being in the pursuit of truths and practices that grant human dignity to everybody, per the university’s Vision 130.” 

Miranda added that participating in the task team will create larger benefits for the UFS. “This will also help in co-creating an inclusive environment where CUADS would seamlessly and holistically be integrated into every part of the UFS. It is an opportunity to gain exposure to experiences and practices of other HEIs and identify possible solutions for the UFS to achieve its strategic goal in advancing a transformational institutional culture demonstrating its values.” 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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