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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

News Archive

UFS celebrates establishment of a new department

2008-09-26

At the celebration of the establishment of the Department of Genetics are, from the left: Prof. Herman van Schalkwyk, Dean: Faculty of Natural and Agricultural Sciences at the UFS, Prof. Johan Spies, head of the Department of Genetics at the UFS, Prof. Chris Viljoen, associate professor at the UFS Department of Haematology and Cell Biology and previously associated with the Department of Genetics; seated: Prof. Paul Grobler, associate professor at the UFS Department of Genetics.
Photo: Stephen Collett

UFS celebrates establishment of a new department

The establishment of the Department of Genetics in the Faculty of Natural and Agricultural Sciences at the University of the Free State (FS) was recently celebrated on the Main Campus in Bloemfontein.

The department, which formed part of the Department of Plant Sciences, is the only of its kind in the country that conducts research in behavioural genetics. “With behavioural genetics we try to determine if certain human behaviour is hereditary or if it is as a result of the environment. Although this is the fastest growing field of specialty in the United States of America, it is still an unknown field in South Africa,” says Prof. Johan Spies, head of the Department of Genetics.

The other specialty fields of the department are forensic genetics and conservation genetics. “Forensic genetics looks at the compilation of the DNA of animals. Because of our academics’ expertise, the department is regularly requested by the South African Police Service to assist them with establishing the origin of animals – especially in the case of game poaching. We recently completed a research project on cheetahs where we had to establish if they were acquired illegally of part of the farmer’s game. The research showed that the cheetahs were part of the farmer’s own breed,” says Prof. Spies.

Another specialty field of the department is conservation genetics where the genetic variance of animals is researched. A lot of research is done on vervet monkeys to determine from which area in the country they originate. The study must be completed before the 3000 vervet monkeys currently in rehabilitation centres are set free. The behaviour of monkeys in rehabilitation is also being researched.

Prof. Spies says: “Student figures in Genetics show an annual increase of 8% per year for the past five years. The first group of master’s degree students in Genetics will start their studies next year.” The department is also regarded as a leader on Clivia research.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za
25 September 2008

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