Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

UFS is the most integrated campus in the country
2010-01-29

 
 Judge Ian van der Merwe, Chairperson of the University of the Free State's (UFS) Council and Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS at the official opening ceremony.
Photo: Hannes Pieterse

“The University of the Free State’s (UFS) Main Campus is the most integrated campus in the country.”

This was said by Prof. Jonathan Jansen, Rector and Vice-Chancellor of the UFS during the university’s official opening on its Main Campus in Bloemfontein today.

Addressing staff and students, Prof. Jansen said that the first-year students in the majority of the residences are now fully integrated on a 50/50 basis. “The majority of our house committees are now also integrated,” he said.

He used the ladies residence Welwitschia as an example. “When I walked into to this residence last year it consisted only of black female students. When I visited them again this year I could not believe what I saw: the residence is fully integrated and there are white and black students living together. This is an example of our young people’s willingness to live together and we must believe in their potential,” he said.

Prof. Jansen said that the UFS does not want to be good because “good is the enemy of great” (from Jim Collins in his book Good to Great). “We want to be great. This is the year in which our staff and students’ lives will change and this university will change as we take the first steps in making the leap from good to great,” he said.

Prof. Jansen said that there have been many developments at the UFS so far this year. “We have attracted some of the best scholars in the country and other parts of the world to this university, and we will be selecting from among them in the next two weeks. We have also attracted some of the best athletes in the country in our first-year class, including some of the best hockey players,” he said.

Prof. Jansen outlined the following as his priorities for 2010:

  • The phasing in of compulsory class attendance as a way to drastically improve the quality of teaching at the UFS. “This will also enhance our throughput. However, before we can to this, we are going to accelerate the building of larger classrooms to accommodate all our students,” he said.
  • The appointment of a senior vice-rector in the near future, who will manage the day to day operations of the UFS;
  • To market the UFS to the best and most promising schools in South Africa. “This will start next week when I will be visiting schools in the Eastern Cape.”
  • To raise R100 million to enable more students with talent to study at the UFS, and to build an endowment to be proud of for the future of the university;
  • To upgrade the infrastructure in the residences;
  • To require every member of the university’s academic staff to publish every year;
  • To train administrative and support staff so that a world-class service culture can be created which takes every student, every parent and every staff member seriously; and
  • To insist that the conditions of service of staff working for agencies outside the UFS be improved by increasing the minimum remuneration dramatically and by making study benefits available to them as well. “We will not renew our tenders with outside agencies unless they raise the minimum wage of their staff,” he said.

Prof. Jansen said that he was extremely proud of the Student Representative Council’s (SRC) leadership and what they have achieved so far during their term. He also thanked the staff for their hard work and the excellence they bring to the UFS.
 

Media release
Issued by: Lacea Loader
Director: Strategic Communication (actg)
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl@ufs.ac.za  
29 January 2010
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept