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12 December 2024 | Story André Damons | Photo André Damons
Dr Innocensia Mangoato
Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. Here she is with her supervisor and mentor Prof Motlalepula Matsabisa, Director of the University of the Free State (UFS) Department of Pharmacology.

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field. 

News Archive

Kovsies blossom with potential
2010-02-04

Pictured with Prof Jansen are, from the left: Marike Botha, Sibusiso Tshabalala, Cumine de Villiers, Portia Lehasa and Meyer Joubert.
Photo: Hannes Pieterse


The Rector and Vice-Chancellor of the University of the Free State (UFS), Prof. Jonathan Jansen, recently made closer acquaintance with five top Grade 12 achievers who are currently first-year students at the UFS.

The five students all achieved exceptional results in their final exams.

Cumine de Villiers from the Volkskool Secondary School in Potchefstroom obtained seven distinctions. She is an MBChB I student and resides in Roosmaryn Residence on the Main Campus. People are her passion, which makes a career as a doctor ideal for her. “I can help people physically, as well as emotionally. And save lives!” Her advice to learners is to work hard from Grade 11 already. According to her a balanced life is also very important: “The more you do, the better you can do.” One of her goals is to learn Sesotho while she is studying.

Marike Botha attended Potchefstroom Gymnasium. She obtained seven distinctions. She is also studying MBChB I and plans to become a paediatric surgeon. “I know one is going to lose patients, but one will also save lives.”

She resides in Roosmaryn Residence and plans to enjoy her student life to the full: “I am going to attend everything! Every dance, rugby match and serenade – there are some things in life that one can only experience once, and one’s first year is one of those.” According to her, the Grade 12 work is not that difficult; it is only a lot. She advises matriculants to always to their best and never to leave anything till later.

Sibusiso Tshabalala from HTS Welkom obtained three distinctions. He is studying BCom Law. He chose that degree because it perfectly integrates law and commerce. “In that way I am keeping my career options open”. He chose Kovsies for the opportunity to be part of one of the best Faculties of Law in South Africa. He resides in JBM Hertzog Residence. His advice to matriculants is to fully make use of every opportunity. “There will be setbacks – it is not supposed to be easy. All of that makes you a stronger person. Strive after your own goals – don’t measure them against others’ goals.”

Portia Lehasa from Eunice High School obtained five distinctions. She is studying BA Accounting and resides in Roosmaryn Residence. She chose Kovsies in order to be part of the transformation.

“Transformation leads to growth – and growth is essential for all persons.” She chose accounting because she enjoys challenges. “It is also a skill that will enable me to empower the economic status of South Africa.”

She also wants to become involved in everything on campus and make a difference. “You are going to see me a lot – I am going to change the world!” She also has some advice for matriculants: “It is very important to have a goal. In that way one still has something to strive for. It helps incredibly.”

Meyer Joubert attended the Ferdinand Postma Secondary School in Potchefstroom. He obtained seven distinctions. He is an MBChB I student and resides in Abraham Fischer Residence. “One’s life only becomes meaningful once one does something for someone else; that is why I want to become a doctor. By means of medicine one can make a difference to someone else’s life.” He plans to become the best doctor possible. According to him learners can take it leisurely up to Grade 10. “The requirements for many fields of study, like medicine, already apply from Grade 10. Therefore it is important to start to focus and work hard from then onwards. However, don’t only study! Balance is very important; therefore participate in sports, cultural activities and, of course, socialise.”

Prof. Jansen was, rightly so, impressed by all the talent that have settled at Kovsies this year: “This is only the beginning. With so much potential Kovsies can blossom!”

Media Release:
Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt@ufs.ac.za  
4 February 2010
 

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