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PhD study investigates cannabis as potential cancer treatment

12 December 2024 | Story André Damons | Photo André Damons

A lecturer and researcher from the University of the Free State (UFS) Department of Pharmacology hopes her research into the use of cannabis in reversing anticancer drug resistance is a step forward into treating various cancers especially in Southern Africa.

Dr Innocensia Mangoato graduated on Tuesday (10 December 2024) with the degree Doctor of Philosophy with specialisation in pharmacology at the Faculty of Health Sciences’ December graduation ceremony. She started her career as a research scientist in the area of African traditional medicines in 2018 and her research received both national and international recognition.

“It’s an amazing (feeling to graduate today). My PhD journey was smooth and beautiful and with mentorship of Prof (Motlalepula) Matsabisa, who groomed me well, I did not shed a tear,” said Dr Mangoato. Dr Gudrun S Ulrich-Merzenich from the University of Bonn in Germany, was her co-supervisor with Prof Matsabisa.

According to the graduation programme, Dr Mangoato, Lecturer and Researcher in the UFS Department of Pharmacology, with her thesis titled Investigating the anticancer and possible resistant reversal effects of cannabis sativa l. extracts in cervical cancer cell lines and modulation of ABC transporters comprehensively explored the therapeutic potential of Cannabis sativa L. in overcoming drug resistance in cervical cancer using in vitro and network pharmacology approaches.

A step forward for treating various cancers

The research looked at the chemical fingerprints and pharmacological targets of C. sativa L. extracts, highlighting its antiproliferative properties against normal non-cancerous cells, cervical cancer cells and the cisplatin-resistant cervical cancer cells. Through PCR analysis, distinct gene expression profiles were identified, revealing the potential effects of combination treatments to counteract cisplatin resistance by downregulating genes associated with drug transporters and crucial signalling pathways. This work provides valuable insights into innovative therapeutic strategies for improving cervical cancer treatment, highlighting new avenues for overcoming resistance and enhancing treatment efficacy though the possible use of plant extracts.

“I hope my research takes a step forward in treating various cancers – especially gynaecology cancers in the Southern Hemisphere in Africa. Hopefully the research can later transcend into clinical trials and hopefully influence more policymakers. We also hope to further develop cannabis to be used as an adjuvant therapy for those drugs that are failing to treat cancer,” says Dr Mangoato, who was the recipient of the Women in Science Master’s Student in 2018.

Her graduation was also a proud moment for Prof Matsabisa, an expert in traditional African medicine, who was like a father to her during her studies. “Prof identified me from my honours degree and walked this journey with me. He has been a great mentor, a father and an amazing supervisor.”

Dr Mangoato says she will for now focus on research only and helping and monitoring upcoming researchers, especially female researchers as there is a scarcity of them her field.

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Recognition from the United Nations and MACE

2013-11-22

The University of the Free State received Excellence and Merit awards for its communication and marketing projects.

From the left is Leatitia Pienaar, editor of Bult magazine, Lacea Loader, Director Strategic Communication, Leonie Bolleurs, editor of Dumela and Ilze Bakkes, UFS Marketer: Publications and Broadcast.
Photo: Sonia Small

The University of the Free State (UFS) was this week recognised by the United Nations (UN), as well as the national association for Marketing, Advancement and Communication in Education (MACE), for its communication and marketing publications and campaigns.

The UFS was named by representatives of the UN to receive a special United Nations Award for a leadership communication campaign called ‘Talk to me’. The award, which forms part of the Golden Awards of the International Public Relations Association (IPRA), is made annually to the campaign that best supports human development in line with the UN objectives.

The UFS also received seven awards from MACE during the Higher and Further Education Excellence Awards. The ‘Talk to me’ campaign was awarded an Excellence Award in the category integrated campaigns and projects; a television campaign on DSTV received an Excellence Award in the broadcasting category. The campaign also received an award as the overall winner in this category. The magazine Bult received a special Excellence Award in the category external publications (as the publication with the highest marks in the history of this award ceremony); the staff newsletter Dumela and a set of student recruitment publications each received a Merit Award in the categories internal newsletters and special publications respectively; and the Open Day campaign received a Merit Award in the category integrated campaigns and projects.

The Excellence Awards form part of the 2013 national MACE congress, which was hosted by the UFS on the Bloemfontein Campus from 18-20 November 2013 and attended by 139 delegates from 25 higher and further education institutions.

“I am extremely proud of the achievements of what is emerging as a truly world-class communications department at the UFS recognised increasingly for achievements nationally and abroad,” says Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS.

‘Talk to me’, which was implemented in 2010, is a leadership communication campaign that creates a way for staff and students to engage with Prof Jansen. With the campaign, he regularly spends time physically sitting on the university’s three campuses in a predetermined area giving staff and students the opportunity to talk and interact with him. The success of the campaign stems from the fact that it gives him the opportunity to pick up on issues or concerns of the campus community.

“The ‘Talk to me’ campaign is one of the key campaigns of the university’s Human Project, as it projects the scholarship of service and transformation leadership. It is an exceptional honour to be recognised by the UN and to receive this award,” says Lacea Loader, Director: Strategic Communication at the UFS.

“The MACE Higher and Further Education Excellence Awards provide an excellent platform to showcase the many projects and campaigns of the sector, and to receive this kind of recognition from our peers is a tremendous honour for the UFS,” says Loader.

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